Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAF1 | P04049 | 7/20 | 0.60 |
| ▸ | ULK1 | O75385 | 1/20 | 0.60 |
| ▸ | KIF15 | Q9NS87 | 1/20 | 0.60 |
| ▸ | EGFR | P00533 | 2/20 | 0.54 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.54 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.54 |
| ▸ | PLK4 | O00444 | 1/20 | 0.53 |
| ▸ | PLK1 | P53350 | 1/20 | 0.53 |
| ▸ | LRRK2 | Q5S007 | 4/20 | 0.52 |
| ▸ | AURKA | O14965 | 1/20 | 0.52 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.49 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.49 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.49 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.49 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.49 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.49 |
| ▸ | NEK2 | P51955 | 3/20 | 0.47 |
| ▸ | CDK1 | P06493 | 1/20 | 0.47 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.47 |
| ▸ | IGF1R | P08069 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5773006 | 1.00 | RAF1 (0.60) | RAF1ULK1KIF15EGFRERBB2 | |
| SCHEMBL5775133 | 0.88 | RAF1 (0.63) | RAF1ULK1KIF15EGFRERBB2 | |
| SCHEMBL5775129 | 0.88 | RAF1 (0.63) | RAF1ULK1KIF15EGFRERBB2 | |
| SCHEMBL5799355 | 0.87 | RAF1 (0.75) | RAF1KIF15EGFRERBB2PDGFRB | |
| SCHEMBL5799357 | 0.87 | RAF1 (0.75) | RAF1KIF15EGFRERBB2PDGFRB | |
| SCHEMBL5774244 | 0.87 | RAF1 (0.78) | RAF1ULK1KIF15EGFRERBB2 | |
| SCHEMBL5774247 | 0.87 | RAF1 (0.78) | RAF1ULK1KIF15EGFRERBB2 | |
| SCHEMBL5773597 | 0.84 | RAF1 (0.67) | RAF1ULK1KIF15EGFRERBB2 | |
| SCHEMBL5773594 | 0.84 | RAF1 (0.67) | RAF1ULK1KIF15EGFRERBB2 | |
| SCHEMBL5774703 | 0.83 | RAF1 (0.58) | RAF1ULK1KIF15EGFRERBB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1003721-B1 | BENZYLIDENE-1,3-DIHYDRO-INDOL-2-ONE DERIVATIVES AS RECEPTOR TYROSINE KINASE INHIBITORS, PARTICULARLY OF RAF KINASES | GLAXO GROUP LTD (GB) | 2006-11-02 | — | — | EP | disclosed |
| US-6268391-B1 | Benzylidene-1,3-dihydro-indol-2-one derivatives a receptor tyrosine kinase inhibitors, particularly of Raf kinases | GLAXO WELLCOME INC. | 2001-07-31 | — | — | US | disclosed |