Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 19/20 | 0.83 |
| ▸ | CYP3A4 | P08684 | 9/20 | 0.59 |
| ▸ | EGFR | P00533 | 2/20 | 0.57 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.57 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.57 |
| ▸ | PRKD2 | Q9BZL6 | 2/20 | 0.57 |
| ▸ | ABL1 | P00519 | 1/20 | 0.57 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.57 |
| ▸ | FYN | P06241 | 1/20 | 0.57 |
| ▸ | PIM1 | P11309 | 1/20 | 0.57 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.57 |
| ▸ | FLT4 | P35916 | 1/20 | 0.57 |
| ▸ | KDR | P35968 | 1/20 | 0.57 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.57 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.57 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.57 |
| ▸ | CDC42BPA | Q5VT25 | 1/20 | 0.57 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5773221 | 1.00 | MAPK14 (0.83) | MAPK14CYP3A4EGFRMAPK9CSNK1D | |
| SCHEMBL5772546 | 0.96 | MAPK14 (0.90) | MAPK14CYP3A4EGFRMAPK9CSNK1D | |
| SCHEMBL5771972 | 0.93 | MAPK14 (0.85) | MAPK14CYP3A4EGFRMAPK9CSNK1D | |
| SCHEMBL5768867 | 0.92 | MAPK14 (0.71) | MAPK14CYP3A4EGFRMAPK9CSNK1D | |
| SCHEMBL5771351 | 0.92 | MAPK14 (0.71) | MAPK14CYP3A4EGFRMAPK9CSNK1D | |
| SCHEMBL5772472 | 0.92 | MAPK14 (0.84) | MAPK14CYP3A4EGFRMAPK9CSNK1D | |
| SCHEMBL5771288 | 0.91 | MAPK14 (0.69) | MAPK14CYP3A4EGFRMAPK9CSNK1D | |
| SCHEMBL5771291 | 0.91 | MAPK14 (0.69) | MAPK14CYP3A4EGFRMAPK9CSNK1D | |
| SCHEMBL4833479 | 0.91 | MAPK14 (1.00) | MAPK14CYP3A4EGFRMAPK9CSNK1D | |
| SCHEMBL5774303 | 0.91 | MAPK14 (0.81) | MAPK14CYP3A4EGFRMAPK9CSNK1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1554272-B1 | BENZIMIDAZOLES AND BENZOTHIAZOLES AS INHIBITORS OF MAP KINASE | LILLY CO ELI (US) | 2006-10-25 | — | — | EP | disclosed |