Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 3/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.41 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.41 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.41 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5773229 | 1.00 | HPGD (0.50) | HPGDALDH1A1USP2KMT2AMEN1 | |
| SCHEMBL11482047 | 0.82 | HPGD (0.52) | HPGDALDH1A1USP2KMT2AMEN1 | |
| SCHEMBL11482052 | 0.82 | HPGD (0.52) | HPGDALDH1A1USP2KMT2AMEN1 | |
| SCHEMBL5770772 | 0.81 | SMN1; SMN2 (0.42) | HPGDALDH1A1KMT2AMEN1NPC1 | |
| SCHEMBL5776074 | 0.80 | HPGD (0.60) | HPGDALDH1A1USP2KMT2AMEN1 | |
| SCHEMBL5776078 | 0.80 | HPGD (0.60) | HPGDALDH1A1USP2KMT2AMEN1 | |
| SCHEMBL11475019 | 0.80 | HPGD (0.55) | HPGDALDH1A1USP2KMT2AMEN1 | |
| SCHEMBL10573027 | 0.80 | HPGD (0.60) | HPGDALDH1A1USP2KMT2AMEN1 | |
| SCHEMBL9366034 | 0.78 | HPGD (0.63) | HPGDALDH1A1USP2KMT2AMEN1 | |
| SCHEMBL9366030 | 0.78 | HPGD (0.63) | HPGDALDH1A1USP2KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1054887-B1 | BICYCLIC PYRIDINE AND PYRIMIDINE DERIVATIVES AS NEUROPEPTIDE Y RECEPTOR ANTAGONISTS | AMGEN INC (US) | 2006-04-12 | — | — | EP | disclosed |
| US-6583154-B1 | Neuropeptide Y antagonist; pyrrolo-(3,2-b)pyridines and pyrrolo-(3,2-d)pyrimidines | AMGEN INC. | 2003-06-24 | — | — | US | disclosed |
| US-6187777-B1 | PYRROLO(3,2-D)PYRIMIDINE DERIVATIVES; NEUROPEPTIDE Y AND CORTICOTROPIN RELEASING FACTOR MODULATORS; DIETETICS; ANTIDIABETIC, ANTIINFLAMMATORY, AND ANTITUMOR AGENTS | AMGEN INC. | 2001-02-13 | — | — | US | disclosed |