Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPY5R | Q15761 | 14/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL5776807 | 0.97 | NPY5R (0.50) | NPY5RKMT2AHSD17B10HRH4KDM4E | |
| SCHEMBL5771896 | 0.97 | NPY5R (0.52) | NPY5RKMT2AHSD17B10KDM4EL3MBTL1 | |
| SCHEMBL5773681 | 0.96 | NPY5R (0.54) | NPY5RKMT2AHSD17B10KDM4EL3MBTL1 | |
| Hydrochloric Acid SCHEMBL5777287 | 0.95 | NPY5R (0.50) | NPY5RKMT2AHSD17B10KDM4EL3MBTL1 | |
| SCHEMBL5774815 | 0.90 | NPY5R (0.54) | NPY5RKMT2AHSD17B10HRH4KDM4E | |
| SCHEMBL5772625 | 0.90 | MELK (0.45) | NPY5RHSD17B10HRH4KDM4E | |
| SCHEMBL5773980 | 0.89 | NPY5R (0.55) | NPY5RKMT2AHSD17B10KDM4EL3MBTL1 | |
| SCHEMBL5775329 | 0.88 | KDM4E (0.45) | NPY5RHSD17B10KDM4E | |
| Hydrochloric Acid SCHEMBL5773699 | 0.88 | MELK (0.44) | NPY5RHSD17B10HRH4KDM4E | |
| SCHEMBL8126501 | 0.87 | NPY5R (0.46) | NPY5RHSD17B10HRH4KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1054887-B1 | BICYCLIC PYRIDINE AND PYRIMIDINE DERIVATIVES AS NEUROPEPTIDE Y RECEPTOR ANTAGONISTS | AMGEN INC (US) | 2006-04-12 | — | — | EP | claimed |
| US-6187777-B1 | PYRROLO(3,2-D)PYRIMIDINE DERIVATIVES; NEUROPEPTIDE Y AND CORTICOTROPIN RELEASING FACTOR MODULATORS; DIETETICS; ANTIDIABETIC, ANTIINFLAMMATORY, AND ANTITUMOR AGENTS | AMGEN INC. | 2001-02-13 | — | — | US | claimed |