Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPY5R | Q15761 | 14/20 | 0.46 |
| ▸ | SCN10A | Q9Y5Y9 | 6/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.41 |
| ▸ | SCN1A | P35498 | 1/20 | 0.41 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.41 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.41 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.41 |
| ▸ | SCN8A | Q9UQD0 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5776833 | 0.85 | NPY5R (0.47) | NPY5RSCN10AKCNH2SCN1ASCN5A | |
| SCHEMBL5773825 | 0.84 | NPY5R (0.61) | NPY5R | |
| SCHEMBL5774511 | 0.81 | NPY5R (0.60) | NPY5R | |
| SCHEMBL5770751 | 0.81 | NPY5R (0.58) | NPY5R | |
| SCHEMBL5773389 | 0.79 | NPY5R (0.50) | NPY5R | |
| SCHEMBL5773103 | 0.78 | NPY5R (0.77) | NPY5R | |
| SCHEMBL5773995 | 0.78 | NPY5R (0.68) | NPY5R | |
| Hydrochloric Acid SCHEMBL5772737 | 0.77 | NPY5R (0.74) | NPY5R | |
| SCHEMBL5774435 | 0.76 | NPY5R (0.48) | NPY5RSCN2A | |
| SCHEMBL5775579 | 0.74 | NPY5R (0.45) | NPY5R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1054887-B1 | BICYCLIC PYRIDINE AND PYRIMIDINE DERIVATIVES AS NEUROPEPTIDE Y RECEPTOR ANTAGONISTS | AMGEN INC (US) | 2006-04-12 | — | — | EP | disclosed |
| US-6583154-B1 | Neuropeptide Y antagonist; pyrrolo-(3,2-b)pyridines and pyrrolo-(3,2-d)pyrimidines | AMGEN INC. | 2003-06-24 | — | — | US | disclosed |
| US-6187777-B1 | PYRROLO(3,2-D)PYRIMIDINE DERIVATIVES; NEUROPEPTIDE Y AND CORTICOTROPIN RELEASING FACTOR MODULATORS; DIETETICS; ANTIDIABETIC, ANTIINFLAMMATORY, AND ANTITUMOR AGENTS | AMGEN INC. | 2001-02-13 | — | — | US | disclosed |