Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.46 |
| ▸ | ELANE | P08246 | 1/20 | 0.45 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.44 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.44 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.44 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL812662 | 0.89 | NPC1 (0.53) | NPC1RAB9AELANEHSD17B10ALDH1A1 | |
| SCHEMBL4029088 | 0.87 | ELANE (0.58) | NPC1RAB9AELANEHSD17B10TSHR | |
| SCHEMBL30025603 | 0.87 | ELANE (0.58) | NPC1RAB9AELANEHSD17B10TSHR | |
| SCHEMBL4028915 | 0.84 | ELANE (0.54) | NPC1RAB9AELANEHSD17B10TSHR | |
| SCHEMBL7869611 | 0.84 | NPC1 (0.51) | NPC1RAB9AELANEHSD17B10ALDH1A1 | |
| SCHEMBL2882726 | 0.83 | NPC1 (0.58) | NPC1RAB9AHSD17B10ALDH1A1KDM4E | |
| SCHEMBL5307439 | 0.81 | NPC1 (0.60) | NPC1RAB9AELANEHSD17B10TSHR | |
| SCHEMBL311688 | 0.81 | NPC1 (0.54) | NPC1RAB9AHSD17B10ALDH1A1KDM4E | |
| SCHEMBL3791447 | 0.81 | NPC1 (0.63) | NPC1RAB9AELANEHSD17B10ALDH1A1 | |
| SCHEMBL5307520 | 0.81 | TNKS (0.54) | NPC1RAB9AELANEALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1558260-A4 | QUINAZOLINONE COMPOUNDS AS CALCILYTICS | NPS PHARMA INC (US) | 2006-10-25 | — | — | EP | disclosed |
| EP-1558260-A2 | QUINAZOLINONE COMPOUNDS AS CALCILYTICS | NPS PHARMACEUTICALS, INC. (US) | 2005-08-03 | — | — | EP | disclosed |
| WO-2004041755-A2 | QUINAZOLINONE COMPOUNDS AS CALCILYTICS | NPS PHARMACEUTICALS, INC. (US) | 2004-05-21 | — | — | WO | disclosed |