Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SPPL2A | Q8TCT8 | 1/20 | 0.36 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.34 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.34 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.34 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.34 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.34 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.34 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.33 |
| ▸ | MLNR | O43193 | 1/20 | 0.33 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | CTSD | P07339 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP3A5 | P20815 | 1/20 | 0.33 |
| ▸ | CNR1 | P21554 | 1/20 | 0.33 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.33 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5769249 | 0.85 | SPPL2A (0.37) | SPPL2APSEN1PSEN2APH1BNCSTN | |
| SCHEMBL12709310 | 0.82 | SPPL2A (0.44) | SPPL2APSEN1PSEN2APH1BNCSTN | |
| SCHEMBL12709389 | 0.81 | KLK5 (0.43) | SPPL2APSEN1PSEN2APH1BNCSTN | |
| SCHEMBL6763207 | 0.79 | ABCB1 (0.56) | MLNRABCB11LMNACTSDCYP3A4 | |
| SCHEMBL1602261 | 0.79 | ABCB1 (0.56) | MLNRABCB11LMNACTSDCYP3A4 | |
| SCHEMBL1602262 | 0.79 | ABCB1 (0.56) | MLNRABCB11LMNACTSDCYP3A4 | |
| SCHEMBL5770753 | 0.78 | SPPL2A (0.45) | SPPL2APSEN1PSEN2APH1BNCSTN | |
| SCHEMBL1601920 | 0.77 | SPPL2A (0.41) | SPPL2AMLNRABCB11LMNACTSD | |
| SCHEMBL1601922 | 0.77 | SPPL2A (0.41) | SPPL2AMLNRABCB11LMNACTSD | |
| SCHEMBL12709200 | 0.77 | SPPL2A (0.44) | SPPL2APSEN1PSEN2APH1BNCSTN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1637518-A2 | Inhibitors of aspartyl protease | Vertex Pharmaceuticals Incorporated (US) | 2006-03-22 | — | — | EP | disclosed |