Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAF1 | P04049 | 11/20 | 0.77 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.70 |
| ▸ | JAK3 | P52333 | 1/20 | 0.66 |
| ▸ | AURKA | O14965 | 1/20 | 0.62 |
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.57 |
| ▸ | MAP1LC3B | Q9GZQ8 | 3/20 | 0.57 |
| ▸ | KIF15 | Q9NS87 | 2/20 | 0.57 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.57 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.57 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.57 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.57 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.57 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.57 |
| ▸ | EGFR | P00533 | 1/20 | 0.57 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.57 |
| ▸ | ARAF | P10398 | 1/20 | 0.57 |
| ▸ | PIM1 | P11309 | 1/20 | 0.57 |
| ▸ | BRAF | P15056 | 1/20 | 0.57 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.57 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5774564 | 1.00 | RAF1 (0.77) | RAF1PIK3C3JAK3AURKALRRK2 | |
| SCHEMBL1394485 | 0.89 | RAF1 (0.61) | RAF1PIK3C3JAK3AURKALRRK2 | |
| SCHEMBL1394486 | 0.89 | RAF1 (0.61) | RAF1PIK3C3JAK3AURKALRRK2 | |
| SCHEMBL1394544 | 0.88 | JAK3 (0.66) | RAF1PIK3C3JAK3KIF15PLK4 | |
| SCHEMBL1394541 | 0.88 | JAK3 (0.66) | RAF1PIK3C3JAK3KIF15PLK4 | |
| SCHEMBL5080490 | 0.88 | RAF1 (0.80) | RAF1PIK3C3AURKALRRK2MAP1LC3B | |
| SCHEMBL1394700 | 0.88 | RAF1 (0.80) | RAF1PIK3C3AURKALRRK2MAP1LC3B | |
| SCHEMBL1394836 | 0.87 | RAF1 (1.00) | RAF1PIK3C3JAK3AURKALRRK2 | |
| SCHEMBL1394837 | 0.87 | RAF1 (1.00) | RAF1PIK3C3JAK3AURKALRRK2 | |
| SCHEMBL5772199 | 0.82 | RAF1 (1.00) | RAF1PIK3C3JAK3AURKALRRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1003721-B1 | BENZYLIDENE-1,3-DIHYDRO-INDOL-2-ONE DERIVATIVES AS RECEPTOR TYROSINE KINASE INHIBITORS, PARTICULARLY OF RAF KINASES | GLAXO GROUP LTD (GB) | 2006-11-02 | — | — | EP | disclosed |