Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.57 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.45 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.42 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.40 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.40 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.39 |
| ▸ | GPR119 | Q8TDV5 | 8/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.38 |
| ▸ | HSP90B1 | P14625 | 1/20 | 0.38 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.37 |
| ▸ | GCK | P35557 | 2/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6282952 | 0.86 | HSP90AA1 (0.40) | MAPTPDGFRBHSP90AA1HSP90B1ENPP2 | |
| SCHEMBL21528039 | 0.85 | MAPT (0.63) | MAPTESR2NR1H2DDB1CRBN | |
| SCHEMBL30805586 | 0.85 | MAPT (0.63) | MAPTESR2NR1H2DDB1CRBN | |
| SCHEMBL21528090 | 0.84 | MAPT (0.62) | MAPTESR2NR1H2DDB1CRBN | |
| SCHEMBL786189 | 0.81 | MAPT (0.65) | MAPTESR2NR1H2DDB1CRBN | |
| SCHEMBL29421798 | 0.81 | ESR2 (0.47) | MAPTESR2NR1H2GPR119GCK | |
| SCHEMBL23301570 | 0.80 | ESR2 (0.54) | MAPTESR2NR1H2GPR119SCN9A | |
| SCHEMBL29723003 | 0.80 | ESR2 (0.51) | MAPTESR2NR1H2GPR119SCN9A | |
| SCHEMBL29712337 | 0.80 | ESR2 (0.54) | MAPTESR2NR1H2GPR119SCN9A | |
| SCHEMBL18550268 | 0.79 | MAPT (0.59) | MAPTESR2NR1H2DDB1CRBN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1483257-B1 | QUINAZOLINE COMPOUNDS USEFUL IN THERAPY | PFIZER LTD (GB) | 2006-09-13 | — | — | EP | disclosed |