Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR1 | P21554 | 19/20 | 0.71 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.46 |
| ▸ | CNR2 | P34972 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5774830 | 0.91 | CNR1 (0.70) | CNR1MALT1CNR2 | |
| SCHEMBL5943014 | 0.86 | CNR1 (0.63) | CNR1CNR2 | |
| SCHEMBL4457218 | 0.84 | CNR1 (1.00) | CNR1 | |
| SCHEMBL5943307 | 0.78 | CNR1 (0.80) | CNR1CNR2 | |
| SCHEMBL5943309 | 0.78 | CNR1 (0.80) | CNR1CNR2 | |
| Hydrochloric Acid SCHEMBL5771259 | 0.77 | CNR1 (0.74) | CNR1 | |
| SCHEMBL30831092 | 0.77 | GRM5 (0.64) | — | |
| SCHEMBL5943018 | 0.76 | CNR1 (0.57) | CNR1CNR2 | |
| SCHEMBL5769982 | 0.75 | CNR1 (1.00) | CNR1CNR2 | |
| SCHEMBL4452937 | 0.74 | CNR1 (0.77) | CNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1641779-A1 | 2-SUBSTITUED 5, 6-DIARYL-PYRAZINE DERIVATIVES AS CB1 MODULATOR. | AstraZeneca AB (SE) | 2006-04-05 | — | — | EP | disclosed |
| WO-2004111033-A1 | 2-SUBSTITUED 5, 6-DIARYL-PYRAZINE DERIVATIVES AS CB1 MODULATOR. | ASTRAZENECA AB (SE) | 2004-12-23 | — | — | WO | disclosed |