Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAU | P00749 | 9/20 | 0.65 |
| ▸ | PLG | P00747 | 6/20 | 0.65 |
| ▸ | PLAT | P00750 | 6/20 | 0.65 |
| ▸ | KLK1 | P06870 | 5/20 | 0.65 |
| ▸ | SLC6A4 | P31645 | 6/20 | 0.46 |
| ▸ | SLC6A2 | P23975 | 4/20 | 0.46 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.46 |
| ▸ | F2 | P00734 | 1/20 | 0.39 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.39 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.39 |
| ▸ | HTR3A | P46098 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | KDM1A | O60341 | 3/20 | 0.31 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.31 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.31 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.31 |
| ▸ | MAOA | P21397 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5778208 | 1.00 | PLAU (0.65) | PLAUPLGPLATKLK1SLC6A4 | |
| SCHEMBL5776089 | 1.00 | PLAU (0.65) | PLAUPLGPLATKLK1SLC6A4 | |
| SCHEMBL5773994 | 0.91 | PLAU (0.65) | PLAUPLGPLATKLK1SLC6A4 | |
| SCHEMBL5774145 | 0.88 | PLAU (0.55) | PLAUPLGPLATKLK1SLC6A4 | |
| SCHEMBL5777859 | 0.84 | PLAU (0.51) | PLAUPLGPLATKLK1SLC6A4 | |
| SCHEMBL5777850 | 0.84 | PLAU (0.51) | PLAUPLGPLATKLK1SLC6A4 | |
| SCHEMBL5778430 | 0.84 | PLAU (0.50) | PLAUPLGPLATKLK1SLC6A4 | |
| SCHEMBL5777137 | 0.83 | PLAU (0.49) | PLAUPLGPLATKLK1SLC6A4 | |
| SCHEMBL5779192 | 0.83 | PLAU (0.51) | PLAUPLGPLATKLK1SLC6A4 | |
| SCHEMBL5777147 | 0.83 | PLAU (0.49) | PLAUPLGPLATKLK1SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1276722-B1 | NAPHTHAMIDINE UROKINASE INHIBITORS | ABBOTT LAB (US) | 2006-03-08 | — | — | EP | disclosed |
| US-6504031-B1 | Enzyme inhibitor such as 6-(2-(1-isopropyl-1,2,3,4-tetrahydro -7-isoquinolinyl)ethenyl)-2-naphthalenecarboximidamide, used as angiogenesis inhibitors; antiarthritic, antiinflammatory and antitumor agents | ABBOTT LABORATORIES | 2003-01-07 | — | — | US | disclosed |
| US-6495562-B1 | SUCH AS 6-(2-(4,4-DIETHYL-1-ISOPROPYL-3,4-DIHYDRO-6-ISOQUINOLINYL)CYCLOPROPYL)-2 -NAPHTHALENECARBOXIMIDAMIDE | ABBOTT LABORATORIES | 2002-12-17 | — | — | US | disclosed |