Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR3 | P51677 | 1/20 | 0.63 |
| ▸ | DRD4 | P21917 | 12/20 | 0.53 |
| ▸ | DRD3 | P35462 | 2/20 | 0.53 |
| ▸ | DRD2 | P14416 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | HTR1A | P08908 | 1/20 | 0.50 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.50 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.50 |
| ▸ | HTR2C | P28335 | 1/20 | 0.50 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | HTR2B | P41595 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5618747 | 0.91 | CCR3 (0.75) | CCR3DRD4DRD3DRD2MEN1 | |
| SCHEMBL5771623 | 0.91 | CCR3 (0.75) | CCR3DRD4DRD3DRD2MEN1 | |
| SCHEMBL5778948 | 0.91 | CCR3 (0.60) | CCR3DRD4DRD3DRD2KDM4E | |
| SCHEMBL5618051 | 0.89 | CCR3 (0.67) | CCR3DRD4DRD3DRD2MEN1 | |
| SCHEMBL5775589 | 0.88 | CCR3 (0.66) | CCR3DRD4DRD3DRD2KDM4E | |
| SCHEMBL5771404 | 0.87 | CCR3 (0.79) | CCR3DRD4DRD3MEN1LMNA | |
| SCHEMBL4028820 | 0.86 | CCR3 (0.58) | CCR3DRD4DRD3DRD2MEN1 | |
| SCHEMBL5776594 | 0.86 | CCR3 (0.70) | CCR3DRD4DRD3KDM4EMEN1 | |
| SCHEMBL5777643 | 0.85 | CCR3 (0.69) | CCR3DRD4DRD3MEN1LMNA | |
| SCHEMBL5777946 | 0.85 | CCR3 (0.64) | CCR3DRD4DRD3KDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1324991-B1 | COMPOUNDS USEFUL IN THE TREATMENT OF INFLAMMATORY DISEASES | GLAXO GROUP LTD (GB) | 2006-11-15 | — | — | EP | disclosed |
| EP-1586567-A1 | Compounds useful in the treatment of inflammatory diseases | GLAXO GROUP LIMITED (GB) | 2005-10-19 | — | — | EP | disclosed |