Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 15/20 | 0.53 |
| ▸ | PDE4B | Q07343 | 15/20 | 0.53 |
| ▸ | PDE4C | Q08493 | 15/20 | 0.53 |
| ▸ | PDE4D | Q08499 | 15/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 13/20 | 0.52 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.52 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5776846 | 0.94 | PDE4A (0.53) | PDE4APDE4BPDE4CPDE4DCYP2C9 | |
| SCHEMBL5776147 | 0.90 | PDE4A (0.51) | PDE4APDE4BPDE4CPDE4DCYP2C9 | |
| SCHEMBL5780648 | 0.89 | PDE4A (0.50) | PDE4APDE4BPDE4CPDE4DCYP2C9 | |
| SCHEMBL5779221 | 0.88 | PDE4A (0.49) | PDE4APDE4BPDE4CPDE4DCYP2C9 | |
| SCHEMBL5776376 | 0.85 | PDE4A (0.56) | PDE4APDE4BPDE4CPDE4DCYP2C9 | |
| SCHEMBL5775052 | 0.85 | PDE4A (0.45) | PDE4APDE4BPDE4CPDE4DCYP2C9 | |
| SCHEMBL5775719 | 0.85 | PTGS1 (0.56) | PDE4APDE4BPDE4CPDE4DCYP2C9 | |
| SCHEMBL5779962 | 0.85 | PDE4A (0.49) | PDE4APDE4BPDE4CPDE4DCYP2C9 | |
| SCHEMBL6220354 | 0.84 | CYP2C9 (0.49) | PDE4APDE4BPDE4CPDE4DCYP2C9 | |
| SCHEMBL6220028 | 0.84 | PDE4A (0.45) | PDE4APDE4BPDE4CPDE4DCYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1635829-A1 | 8-(3-BIARYL)PHENYLQUINOLINE PHOSPHODIESTERASE-4-INHIBITORS | Merck Frosst Canada Ltd. (CA) | 2006-03-22 | — | — | EP | claimed |
| WO-2004096220-A1 | 8-(3-BIARYL)PHENYLQUINOLINE PHOSPHODIESTERASE-4-INHIBITORS | MERCK FROSST CANADA LTD. (CA) | 2004-11-11 | — | — | WO | claimed |
| EP-1635829-A1 | 8-(3-BIARYL)PHENYLQUINOLINE PHOSPHODIESTERASE-4-INHIBITORS | Merck Frosst Canada Ltd. (CA) | 2006-03-22 | — | — | EP | disclosed |
| WO-2004096220-A1 | 8-(3-BIARYL)PHENYLQUINOLINE PHOSPHODIESTERASE-4-INHIBITORS | MERCK FROSST CANADA LTD. (CA) | 2004-11-11 | — | — | WO | disclosed |