Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 9/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 7/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 5/20 | 0.35 |
| ▸ | HTR3A | P46098 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5777208 | 1.00 | SLC6A4 (0.35) | SLC6A4SLC6A2SLC6A3HTR3AKCNH2 | |
| SCHEMBL5775243 | 0.80 | PLAU (0.46) | — | |
| SCHEMBL5775238 | 0.80 | PLAU (0.46) | — | |
| SCHEMBL5780124 | 0.78 | SLC6A4 (0.31) | SLC6A4SLC6A2SLC6A3HTR3AKCNH2 | |
| SCHEMBL5780127 | 0.78 | SLC6A4 (0.31) | SLC6A4SLC6A2SLC6A3HTR3AKCNH2 | |
| SCHEMBL5778397 | 0.75 | PLAU (0.41) | SLC6A4SLC6A2SLC6A3HTR3AKCNH2 | |
| SCHEMBL5778396 | 0.75 | PLAU (0.41) | SLC6A4SLC6A2SLC6A3HTR3AKCNH2 | |
| SCHEMBL5777317 | 0.73 | PLAU (0.41) | SLC6A4SLC6A2SLC6A3HTR3AKCNH2 | |
| SCHEMBL5777320 | 0.73 | PLAU (0.41) | SLC6A4SLC6A2SLC6A3HTR3AKCNH2 | |
| SCHEMBL7354116 | 0.73 | PLAU (0.30) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1276722-B1 | NAPHTHAMIDINE UROKINASE INHIBITORS | ABBOTT LAB (US) | 2006-03-08 | — | — | EP | disclosed |
| EP-1276722-A1 | NAPHTHAMIDINE UROKINASE INHIBITORS | Abbott Laboratories (US) | 2003-01-22 | — | — | EP | disclosed |
| US-6504031-B1 | Enzyme inhibitor such as 6-(2-(1-isopropyl-1,2,3,4-tetrahydro -7-isoquinolinyl)ethenyl)-2-naphthalenecarboximidamide, used as angiogenesis inhibitors; antiarthritic, antiinflammatory and antitumor agents | ABBOTT LABORATORIES | 2003-01-07 | — | — | US | disclosed |
| US-6495562-B1 | SUCH AS 6-(2-(4,4-DIETHYL-1-ISOPROPYL-3,4-DIHYDRO-6-ISOQUINOLINYL)CYCLOPROPYL)-2 -NAPHTHALENECARBOXIMIDAMIDE | ABBOTT LABORATORIES | 2002-12-17 | — | — | US | disclosed |
| WO-2001081314-A1 | NAPHTHAMIDINE UROKINASE INHIBITORS | ABBOTT LABORATORIES (US) | 2001-11-01 | — | — | WO | disclosed |