Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | NPY2R | P49146 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5578851 | 0.96 | NOTUM (0.48) | NOTUMMAPTLMNATSHRHTT | |
| SCHEMBL5578681 | 0.92 | NOTUM (0.50) | NOTUMMAPTLMNATSHRHTT | |
| SCHEMBL5578689 | 0.91 | NOTUM (0.49) | NOTUMMAPTLMNATSHRHTT | |
| SCHEMBL5578704 | 0.89 | NOTUM (0.49) | NOTUMMAPTTSHRHTTL3MBTL1 | |
| SCHEMBL5578835 | 0.87 | NOTUM (0.49) | NOTUMMAPTLMNATSHRHTT | |
| SCHEMBL5579107 | 0.86 | NOTUM (0.48) | NOTUMLMNATSHRHTTL3MBTL1 | |
| SCHEMBL5578888 | 0.86 | NOTUM (0.44) | NOTUMTSHRHTTL3MBTL1SMN1; SMN2 | |
| SCHEMBL5578894 | 0.85 | NOTUM (0.46) | NOTUMMAPTLMNATSHRHTT | |
| SCHEMBL5579066 | 0.83 | NOTUM (0.43) | NOTUMHTTL3MBTL1SMN1; SMN2ALDH1A1 | |
| SCHEMBL5578596 | 0.76 | NOTUM (0.46) | NOTUMTSHRHTTL3MBTL1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1716148-A2 | NOVEL SPIROINDOLINE OR SPIROISOQUINOLINE COMPOUNDS, METHODS OF USE AND COMPOSITIONS THEREOF | Arena Pharmaceuticals, Inc. (US) | 2006-11-02 | — | — | EP | claimed |
| WO-2005063745-A2 | NOVEL SPIROINDOLINE OR SPIROISOQUINOLINE COMPOUNDS, METHODS OF USE AND COMPOSITIONS THEREOF | ARENA PHARMACEUTICALS, INC. (US) | 2005-07-14 | — | — | WO | claimed |