Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNE1 | P24864 | 17/20 | 0.71 |
| ▸ | CDK2 | P24941 | 17/20 | 0.71 |
| ▸ | CDK5 | Q00535 | 17/20 | 0.71 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.46 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.46 |
| ▸ | GLS | O94925 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5781521 | 0.86 | CDK5 (0.55) | CCNE1CDK2CDK5CDK5R1ALDH1A1 | |
| SCHEMBL5779402 | 0.85 | CCNE1 (0.71) | CCNE1CDK2CDK5CDK5R1MAPK9 | |
| SCHEMBL5779348 | 0.83 | CCNE1 (1.00) | CCNE1CDK2CDK5CDK5R1MAPK9 | |
| SCHEMBL5779707 | 0.81 | CCNE1 (0.72) | CCNE1CDK2CDK5CDK5R1 | |
| SCHEMBL5777781 | 0.79 | CCNE1 (1.00) | CCNE1CDK2CDK5CDK5R1GLS | |
| SCHEMBL5782074 | 0.78 | CCNE1 (0.78) | CCNE1CDK2CDK5CDK5R1GLS | |
| SCHEMBL5780891 | 0.77 | CCNE1 (1.00) | CCNE1CDK2CDK5CDK5R1ALDH1A1 | |
| SCHEMBL5779224 | 0.74 | CCNE1 (0.61) | CCNE1CDK2CDK5CDK5R1 | |
| SCHEMBL5781707 | 0.74 | CCNE1 (1.00) | CCNE1CDK2CDK5CDK5R1ALDH1A1 | |
| SCHEMBL5780928 | 0.73 | CCNE1 (0.72) | CCNE1CDK2CDK5CDK5R1GLS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1256578-B1 | Thiazole derivatives and their use as cdk inhibitors | PFIZER PROD INC (US) | 2006-01-11 | — | — | EP | claimed |