Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPY5R | Q15761 | 7/20 | 0.63 |
| ▸ | MAP2K7 | O14733 | 1/20 | 0.41 |
| ▸ | TERT | O14746 | 1/20 | 0.36 |
| ▸ | CRHR1 | P34998 | 6/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | PGK1 | P00558 | 1/20 | 0.33 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.32 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28099824 | 0.69 | NPY5R (0.50) | NPY5RSMN1; SMN2 | |
| SCHEMBL5775761 | 0.69 | NPY5R (0.50) | NPY5RSMN1; SMN2 | |
| SCHEMBL5775448 | 0.69 | NPY5R (0.50) | NPY5RSMN1; SMN2 | |
| SCHEMBL26536326 | 0.67 | NPY5R (0.49) | NPY5RMAP2K7CRHR1SMN1; SMN2LMNA | |
| SCHEMBL24649607 | 0.66 | ACP1 (0.66) | NPY5RSMN1; SMN2LMNA | |
| SCHEMBL26534113 | 0.65 | NPY5R (0.47) | NPY5RMAP2K7CRHR1SMN1; SMN2 | |
| SCHEMBL9127003 | 0.64 | SMN1; SMN2 (0.42) | NPY5RMAP2K7CRHR1SMN1; SMN2PGK1 | |
| SCHEMBL10671138 | 0.60 | SMN1; SMN2 (0.39) | NPY5RMAP2K7CRHR1SMN1; SMN2PGK1 | |
| Hydrochloric Acid SCHEMBL5777141 | 0.59 | NPY5R (0.94) | NPY5R | |
| SCHEMBL20712932 | 0.58 | NPY5R (0.39) | NPY5RSMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1054887-B1 | BICYCLIC PYRIDINE AND PYRIMIDINE DERIVATIVES AS NEUROPEPTIDE Y RECEPTOR ANTAGONISTS | AMGEN INC (US) | 2006-04-12 | — | — | EP | disclosed |
| US-6583154-B1 | Neuropeptide Y antagonist; pyrrolo-(3,2-b)pyridines and pyrrolo-(3,2-d)pyrimidines | AMGEN INC. | 2003-06-24 | — | — | US | disclosed |
| US-6187777-B1 | PYRROLO(3,2-D)PYRIMIDINE DERIVATIVES; NEUROPEPTIDE Y AND CORTICOTROPIN RELEASING FACTOR MODULATORS; DIETETICS; ANTIDIABETIC, ANTIINFLAMMATORY, AND ANTITUMOR AGENTS | AMGEN INC. | 2001-02-13 | — | — | US | disclosed |
| EP-1054887-A1 | BICYCLIC PYRIDINE AND PYRIMIDINE DERIVATIVES AS NEUROPEPTIDE Y RECEPTOR ANTAGONISTS | Amgen Inc. (US) | 2000-11-29 | — | — | EP | disclosed |
| WO-1999040091-A1 | BICYCLIC PYRIDINE AND PYRIMIDINE DERIVATIVES AS NEUROPEPTIDE Y RECEPTOR ANTAGONISTS | AMGEN INC. (US) | 1999-08-12 | — | — | WO | disclosed |