Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 19/20 | 0.37 |
| ▸ | INSR | P06213 | 1/20 | 0.37 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.37 |
| ▸ | KDR | P35968 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5777940 | 1.00 | IGF1R (0.37) | IGF1RINSRFGFR1KDRMEN1 | |
| SCHEMBL217975 | 0.84 | IGF1R (0.45) | IGF1RINSRFGFR1KDRMEN1 | |
| SCHEMBL217676 | 0.73 | JAK2 (0.42) | IGF1RFGFR1KDRMEN1KMT2A | |
| SCHEMBL218889 | 0.72 | IGF1R (0.44) | IGF1RINSRFGFR1KDRNTRK1 | |
| SCHEMBL219273 | 0.69 | IGF1R (0.62) | IGF1RINSRFGFR1KDRMEN1 | |
| SCHEMBL4033781 | 0.66 | IGF1R (0.57) | IGF1RINSRFGFR1KDRMEN1 | |
| SCHEMBL4040614 | 0.66 | IGF1R (0.58) | IGF1RINSRFGFR1KDRMEN1 | |
| SCHEMBL2120929 | 0.66 | IGF1R (0.64) | IGF1RINSRFGFR1KDRMEN1 | |
| SCHEMBL219241 | 0.65 | PLK4 (0.43) | IGF1RKDRMEN1KMT2A | |
| SCHEMBL4034896 | 0.65 | IGF1R (0.60) | IGF1RINSRFGFR1KDRMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1686999-A1 | PYRAZOLE DERIVATIVES AS INHIBITORS OF RECEPTOR TYROSINE KINASES | AstraZeneca AB (SE) | 2006-08-09 | — | — | EP | disclosed |
| WO-2005049033-A1 | PYRAZOLE DERIVATIVES AS INHIBITORS OF RECEPTOR TYROSYNE KINASES | ASTRAZENECA AB (SE) | 2005-06-02 | — | — | WO | disclosed |