Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 10/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | JAK1 | P23458 | 1/20 | 0.35 |
| ▸ | TYK2 | P29597 | 1/20 | 0.35 |
| ▸ | JAK3 | P52333 | 1/20 | 0.35 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5450793 | 0.91 | KCNH2 (0.40) | KCNH2JAK2JAK1TYK2JAK3 | |
| SCHEMBL5777354 | 0.90 | KCNH2 (0.40) | KCNH2JAK2JAK1TYK2JAK3 | |
| SCHEMBL5457752 | 0.83 | KCNH2 (0.47) | KCNH2SCN5A | |
| SCHEMBL5452041 | 0.83 | KCNH2 (0.42) | KCNH2JAK2JAK1TYK2JAK3 | |
| SCHEMBL5472819 | 0.83 | KCNH2 (0.47) | KCNH2SCN5A | |
| SCHEMBL5462500 | 0.82 | KCNH2 (0.46) | KCNH2JAK2JAK1TYK2JAK3 | |
| SCHEMBL14443939 | 0.82 | KCNH2 (0.49) | KCNH2SCN5A | |
| SCHEMBL5450712 | 0.82 | KCNH2 (0.49) | KCNH2SCN5A | |
| SCHEMBL5459526 | 0.82 | KCNH2 (0.45) | KCNH2SCN5A | |
| SCHEMBL5459449 | 0.81 | KCNH2 (0.46) | KCNH2JAK2JAK1TYK2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1687296-A1 | ANTIBACTERIAL AMINOQUINAZOLIDINEDIONE DERIVATIVES | Warner-Lambert Company LLC (US) | 2006-08-09 | — | — | EP | disclosed |
| WO-2005049605-A1 | ANTIBACTERIAL AMINOQUINAZOLIDINEDIONE DERIVATIVES | WARNER-LAMBERT COMPANY LLC (US) | 2005-06-02 | — | — | WO | disclosed |