Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAF1 | P04049 | 7/20 | 0.60 |
| ▸ | MAP1LC3B | Q9GZQ8 | 3/20 | 0.60 |
| ▸ | MAPT | P10636 | 3/20 | 0.60 |
| ▸ | PLK4 | O00444 | 2/20 | 0.60 |
| ▸ | EGFR | P00533 | 1/20 | 0.60 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.60 |
| ▸ | ARAF | P10398 | 1/20 | 0.60 |
| ▸ | PIM1 | P11309 | 1/20 | 0.60 |
| ▸ | BRAF | P15056 | 1/20 | 0.60 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.60 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.60 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.60 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.60 |
| ▸ | MYOC | Q99972 | 1/20 | 0.60 |
| ▸ | DYRK4 | Q9NR20 | 1/20 | 0.60 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.60 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.60 |
| ▸ | MAP3K20 | Q9NYL2 | 1/20 | 0.60 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.60 |
| ▸ | RIPK3 | Q9Y572 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5777978 | 1.00 | RAF1 (0.60) | RAF1MAP1LC3BMAPTPLK4EGFR | |
| SCHEMBL5774364 | 0.89 | RAF1 (0.62) | RAF1MAP1LC3BMAPTPLK4EGFR | |
| SCHEMBL5774367 | 0.89 | RAF1 (0.62) | RAF1MAP1LC3BMAPTPLK4EGFR | |
| SCHEMBL29022186 | 0.78 | RAF1 (0.67) | RAF1MAP1LC3BMAPTPLK4EGFR | |
| SCHEMBL12618366 | 0.77 | RAF1 (0.72) | RAF1MAP1LC3BMAPTPLK4EGFR | |
| SCHEMBL7979136 | 0.77 | RAF1 (0.62) | RAF1MAP1LC3BMAPTPLK4EGFR | |
| SCHEMBL5774275 | 0.77 | RAF1 (0.62) | RAF1MAP1LC3BMAPTPLK4EGFR | |
| Gw305074X SCHEMBL12199472 | 0.76 | RAF1 (1.00) | RAF1MAP1LC3BMAPTPLK4EGFR | |
| Gw305074X SCHEMBL29392050 | 0.76 | RAF1 (1.00) | RAF1MAP1LC3BMAPTPLK4EGFR | |
| Gw305074X SCHEMBL29389948 | 0.76 | RAF1 (1.00) | RAF1MAP1LC3BMAPTPLK4EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1003721-B1 | BENZYLIDENE-1,3-DIHYDRO-INDOL-2-ONE DERIVATIVES AS RECEPTOR TYROSINE KINASE INHIBITORS, PARTICULARLY OF RAF KINASES | GLAXO GROUP LTD (GB) | 2006-11-02 | — | — | EP | disclosed |
| US-6268391-B1 | Benzylidene-1,3-dihydro-indol-2-one derivatives a receptor tyrosine kinase inhibitors, particularly of Raf kinases | GLAXO WELLCOME INC. | 2001-07-31 | — | — | US | disclosed |