Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.35 |
| ▸ | TP53 | P04637 | 5/20 | 0.35 |
| ▸ | PDE2A | O00408 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.35 |
| ▸ | FABP4 | P15090 | 3/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.34 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.34 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.33 |
| ▸ | PTGES | O14684 | 1/20 | 0.33 |
| ▸ | FABP3 | P05413 | 1/20 | 0.32 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.32 |
| ▸ | IDH1 | O75874 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL578133 | 0.90 | PDE2A (0.37) | MAPTTP53PDE2ASMN1; SMN2FABP4 | |
| SCHEMBL577707 | 0.83 | PDE2A (0.39) | MAPTTP53PDE2ASMN1; SMN2FABP4 | |
| SCHEMBL577521 | 0.83 | PDE2A (0.39) | MAPTTP53PDE2ASMN1; SMN2FABP4 | |
| SCHEMBL11926435 | 0.82 | PDE2A (0.38) | MAPTTP53PDE2ASMN1; SMN2FABP4 | |
| SCHEMBL578045 | 0.82 | PDE2A (0.37) | MAPTTP53PDE2ASMN1; SMN2FABP4 | |
| SCHEMBL578162 | 0.82 | PDE2A (0.40) | MAPTTP53PDE2ASMN1; SMN2FABP4 | |
| SCHEMBL577789 | 0.81 | PDE2A (0.39) | MAPTTP53PDE2ASMN1; SMN2FABP4 | |
| SCHEMBL577781 | 0.81 | PDE2A (0.38) | MAPTTP53PDE2ASMN1; SMN2FABP4 | |
| SCHEMBL578370 | 0.81 | ADORA2A (0.43) | MAPTTP53PDE2ASMN1; SMN2MEN1 | |
| SCHEMBL577666 | 0.81 | PTGDR (0.40) | MAPTTP53PDE2ASMN1; SMN2FABP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012109398-A1 | MACROCYCLIC SERINE PROTEASE INHIBITORS, PHARMACEUTICAL COMPOSITIONS THEREOF, AND THEIR USE FOR TREATING HCV INFECTIONS | IDENIX PHARMACEUTICALS, INC. (US) | 2012-08-16 | — | — | WO | disclosed |
| EP-2461811-A1 | MACROCYCLIC SERINE PROTEASE INHIBITORS USEFUL AGAINST VIRAL INFECTIONS, PARTICULARLY HCV | IDENIX Pharmaceuticals, Inc. (US) | 2012-06-13 | — | — | EP | disclosed |
| EP-2417134-A1 | MACROCYCLIC SERINE PROTEASE INHIBITORS | IDENIX Pharmaceuticals, Inc. (US) | 2012-02-15 | — | — | EP | disclosed |
| WO-2011017389-A1 | MACROCYCLIC SERINE PROTEASE INHIBITORS USEFUL AGAINST VIRAL INFECTIONS, PARTICULARLY HCV | IDENIX PHARMACEUTICALS, INC. (US) | 2011-02-10 | — | — | WO | disclosed |
| WO-2010118078-A1 | MACROCYCLIC SERINE PROTEASE INHIBITORS | IDENIX PHARMACEUTICALS, INC. (US) | 2010-10-14 | — | — | WO | disclosed |