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SCHEMBL5778153

SCHEMBL5778153

COc1c(NC(=O)c2ccc(C)c(-n3cc(OC(=O)Nc4ccc(C)cc4)nn3)c2)cc(C(C)(C)C)cc1NS(C)(=O)=O

nearest known ligand 0.47

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
▸ BRAF P15056 19/20 0.47
▸ MAPK14 Q16539 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5780230 0.94 BRAF (0.47) BRAFMAPK14
SCHEMBL5779844 0.94 BRAF (0.47) BRAFMAPK14
SCHEMBL5778882 0.92 BRAF (0.46) BRAFMAPK14
SCHEMBL5778021 0.90 BRAF (0.49) BRAFMAPK14
SCHEMBL5777098 0.90 BRAF (0.51) BRAFMAPK14
SCHEMBL4495344 0.89 BRAF (0.49) BRAFMAPK14
SCHEMBL5775111 0.89 BRAF (0.50) BRAFMAPK14
SCHEMBL5778315 0.88 BRAF (0.47) BRAFMAPK14
SCHEMBL5778570 0.88 BRAF (0.47) BRAFMAPK14
SCHEMBL5779482 0.88 BRAF (0.47) BRAF

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1567507-B1 1,2,3- TRIAZOLE AMIDE DERIVATIVES AS CYTOKINE INHIBITORS BOEHRINGER INGELHEIM PHARMA (US) 2006-06-14 — — EP claimed