Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F10 | P00742 | 3/20 | 0.45 |
| ▸ | BTK | Q06187 | 1/20 | 0.38 |
| ▸ | SUCNR1 | Q9BXA5 | 2/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.36 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.35 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.35 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.35 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.35 |
| ▸ | DHPS | P49366 | 1/20 | 0.35 |
| ▸ | ACHE | P22303 | 1/20 | 0.34 |
| ▸ | KIT | P10721 | 1/20 | 0.34 |
| ▸ | KDR | P35968 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.34 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5781280 | 0.92 | F10 (0.46) | F10HDAC1CDK5DYRK1ACDK5R1 | |
| SCHEMBL5782217 | 0.89 | F10 (0.46) | F10HDAC1DHPSALDH1A1HDAC3 | |
| SCHEMBL5777471 | 0.89 | F10 (0.48) | F10HDAC1DHPSALDH1A1MEN1 | |
| SCHEMBL5782626 | 0.88 | F10 (0.50) | F10HDAC1PDCD1CD274DHPS | |
| SCHEMBL5783180 | 0.88 | F10 (0.48) | F10HDAC1DHPSALDH1A1HDAC3 | |
| SCHEMBL5779859 | 0.88 | F10 (0.48) | F10HDAC1DHPSALDH1A1MEN1 | |
| SCHEMBL5784062 | 0.87 | F10 (0.47) | F10HDAC1DHPSALDH1A1MEN1 | |
| SCHEMBL5783769 | 0.86 | F10 (0.48) | F10HDAC1PDCD1CD274DHPS | |
| SCHEMBL5784722 | 0.85 | F10 (0.49) | F10HDAC1DHPSALDH1A1HDAC3 | |
| SCHEMBL5783655 | 0.85 | F10 (0.45) | F10HDAC1DHPSALDH1A1HDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1408962-B1 | SUBSTITUTED ISOINDOLES AND THE USE THEREOF | BAYER HEALTHCARE AG (DE) | 2006-03-15 | — | — | EP | disclosed |
| EP-1408962-A1 | SUBSTITUTED ISOINDOLES AND THE USE THEREOF | Bayer HealthCare AG (DE) | 2004-04-21 | — | — | EP | disclosed |
| WO-2003007942-A1 | SUBSTITUTED ISOINDOLES AND THE USE THEREOF | BAYER HEALTHCARE AG (DE) | 2003-01-30 | — | — | WO | disclosed |