Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCL1 | Q07820 | 1/20 | 0.46 |
| ▸ | ACMSD | Q8TDX5 | 1/20 | 0.46 |
| ▸ | ENPP3 | O14638 | 1/20 | 0.46 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.46 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.45 |
| ▸ | CA12 | O43570 | 4/20 | 0.44 |
| ▸ | CA1 | P00915 | 4/20 | 0.44 |
| ▸ | CA2 | P00918 | 4/20 | 0.44 |
| ▸ | CA9 | Q16790 | 4/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.44 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25177116 | 0.89 | MCL1 (0.51) | MCL1ACMSDENPP3ENPP1ALDH1A1 | |
| SCHEMBL29195637 | 0.89 | MCL1 (0.51) | MCL1ACMSDENPP3ENPP1ALDH1A1 | |
| SCHEMBL1470544 | 0.89 | MCL1 (0.51) | MCL1ACMSDENPP3ENPP1ALDH1A1 | |
| SCHEMBL29986101 | 0.89 | MCL1 (0.51) | MCL1ACMSDENPP3ENPP1ALDH1A1 | |
| SCHEMBL31742566 | 0.89 | MCL1 (0.54) | MCL1ACMSDENPP3ENPP1ALDH1A1 | |
| SCHEMBL598962 | 0.87 | GSTP1 (0.57) | MCL1ACMSDENPP3ENPP1ALDH1A1 | |
| SCHEMBL30274189 | 0.87 | GSTP1 (0.57) | MCL1ACMSDENPP3ENPP1ALDH1A1 | |
| SCHEMBL3176171 | 0.82 | GSTP1 (0.61) | MCL1ACMSDALDH1A1CYP1A2HPGD | |
| SCHEMBL12344996 | 0.82 | CYP2A6 (0.50) | MCL1ACMSDTLR8ALDH1A1CYP2A6 | |
| SCHEMBL1527419 | 0.81 | HPRT1 (0.54) | MCL1ACMSDALDH1A1CYP2A6CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1615890-A1 | PIPERIDINE DERIVATIVES AS RENIN INHIBITORS FOR THE TREATMENT OF HYPERTENSION | WARNER-LAMBERT COMPANY (US) | 2006-01-18 | — | — | EP | disclosed |
| WO-2004089903-A1 | PIPERIDINE DERIVATIVES AS RENIN INHIBITORS FOR THE TREATMENT OF HYPERTENSION | WARNER-LAMBERT COMPANY LLC (US) | 2004-10-21 | — | — | WO | disclosed |