Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNA2 | P20248 | 1/20 | 0.63 |
| ▸ | CDK2 | P24941 | 1/20 | 0.63 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.63 |
| ▸ | EGFR | P00533 | 11/20 | 0.56 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.56 |
| ▸ | MKNK1 | Q9BUB5 | 6/20 | 0.48 |
| ▸ | RAF1 | P04049 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5629192 | 0.90 | CCNA2 (0.71) | CCNA2CDK2CCNA1EGFRFGFR1 | |
| SCHEMBL5629731 | 0.90 | CCNA2 (0.70) | CCNA2CDK2CCNA1EGFRFGFR1 | |
| SCHEMBL5630755 | 0.89 | CCNA2 (0.69) | CCNA2CDK2CCNA1EGFRFGFR1 | |
| SCHEMBL5630921 | 0.88 | CCNA2 (0.67) | CCNA2CDK2CCNA1EGFRFGFR1 | |
| SCHEMBL5632487 | 0.86 | EGFR (0.65) | EGFRMKNK1 | |
| SCHEMBL5630712 | 0.85 | EGFR (0.52) | CCNA2CDK2CCNA1EGFR | |
| SCHEMBL5629184 | 0.84 | CCNA2 (0.70) | CCNA2CDK2CCNA1EGFRFGFR1 | |
| SCHEMBL5630757 | 0.84 | CCNA2 (0.74) | CCNA2CDK2CCNA1EGFRFGFR1 | |
| SCHEMBL5779839 | 0.84 | CCNA2 (0.64) | CCNA2CDK2CCNA1EGFRFGFR1 | |
| SCHEMBL5631328 | 0.83 | CCNA2 (0.64) | CCNA2CDK2CCNA1EGFRFGFR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7238701-B2 | Substituted tetrahydrobenzothienopyrimidinamine compounds useful for treating hyper-proliferative disorders | BAYER PHARMACEUTICALS CORPORATION (US) | 2007-07-03 | — | — | US | disclosed |
| US-7238701-B2 | Substituted tetrahydrobenzothienopyrimidinamine compounds useful for treating hyper-proliferative disorders | BAYER PHARMACEUTICALS CORPORATION (US) | 2007-07-03 | — | — | US | disclosed |
| EP-1651652-B1 | SUBSTITUTED TETRAHYDROBENZOTHIENOPYRIMIDINAMINE COMPOUNDS USEFUL FOR TREATING HYPER-PROLIFERATIVE DISORDERS | BAYER PHARMACEUTICALS CORP (US) | 2006-12-27 | — | — | EP | disclosed |