Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 13/20 | 0.47 |
| ▸ | PDE4C | Q08493 | 12/20 | 0.47 |
| ▸ | PDE4D | Q08499 | 12/20 | 0.47 |
| ▸ | PDE4B | Q07343 | 10/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 5/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5776443 | 0.93 | PDE4A (0.45) | PDE4APDE4CPDE4DPDE4BCYP2C9 | |
| SCHEMBL5779973 | 0.90 | CYP2C9 (0.42) | PDE4APDE4CPDE4DPDE4BCYP2C9 | |
| SCHEMBL5776217 | 0.89 | MAPK14 (0.43) | PDE4APDE4CPDE4DPDE4BCYP2C9 | |
| SCHEMBL5776143 | 0.89 | CYP2C9 (0.50) | PDE4APDE4CPDE4DPDE4BCYP2C9 | |
| SCHEMBL5776493 | 0.89 | PDE4A (0.46) | PDE4APDE4CPDE4DPDE4BCYP2C9 | |
| SCHEMBL5773581 | 0.88 | CYP2C9 (0.46) | PDE4APDE4CPDE4DPDE4BCYP2C9 | |
| SCHEMBL5813766 | 0.87 | PDE4A (0.51) | PDE4APDE4CPDE4DPDE4BCYP2C9 | |
| SCHEMBL5778745 | 0.86 | PDE4A (0.52) | PDE4APDE4CPDE4DPDE4BCYP2C9 | |
| SCHEMBL5779449 | 0.83 | CYP2C9 (0.45) | PDE4APDE4CPDE4DPDE4BCYP2C9 | |
| SCHEMBL5779217 | 0.81 | CYP2C9 (0.48) | PDE4APDE4CPDE4DPDE4BCYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1635829-A1 | 8-(3-BIARYL)PHENYLQUINOLINE PHOSPHODIESTERASE-4-INHIBITORS | Merck Frosst Canada Ltd. (CA) | 2006-03-22 | — | — | EP | claimed |
| WO-2004096220-A1 | 8-(3-BIARYL)PHENYLQUINOLINE PHOSPHODIESTERASE-4-INHIBITORS | MERCK FROSST CANADA LTD. (CA) | 2004-11-11 | — | — | WO | claimed |
| EP-1635829-A1 | 8-(3-BIARYL)PHENYLQUINOLINE PHOSPHODIESTERASE-4-INHIBITORS | Merck Frosst Canada Ltd. (CA) | 2006-03-22 | — | — | EP | disclosed |
| WO-2004096220-A1 | 8-(3-BIARYL)PHENYLQUINOLINE PHOSPHODIESTERASE-4-INHIBITORS | MERCK FROSST CANADA LTD. (CA) | 2004-11-11 | — | — | WO | disclosed |