SCHEMBL5779488

SCHEMBL5779488

CC(C)COc1ccccc1CCN1CCC2(CC1)CCN(C(=O)c1ccncc1)CC2

nearest known ligand 0.82

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
CCR8 P51685 6/20 0.82
KCNH2 Q12809 6/20 0.82
CYP3A4 P08684 11/20 0.62
CYP2D6 P10635 10/20 0.62
ALDH1A1 P00352 3/20 0.59
TSHR P16473 3/20 0.53
CYP2C19 P33261 1/20 0.53
CYP2C9 P11712 3/20 0.52
CYP1A2 P05177 2/20 0.52
MEN1 O00255 1/20 0.50
KMT2A Q03164 1/20 0.50
HIF1A Q16665 1/20 0.50
USP2 O75604 1/20 0.49
KDM4E B2RXH2 1/20 0.48
HTT P42858 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5396159 0.90 CCR8 (1.00) CCR8KCNH2CYP3A4CYP2D6ALDH1A1
Hydrochloric Acid SCHEMBL5444699 0.89 CCR8 (0.98) CCR8KCNH2CYP3A4CYP2D6ALDH1A1
SCHEMBL5405018 0.85 CCR8 (0.89) CCR8KCNH2CYP3A4CYP2D6ALDH1A1
SCHEMBL5410880 0.84 CCR8 (0.84) CCR8KCNH2CYP3A4CYP2D6ALDH1A1
SCHEMBL5404996 0.83 CCR8 (0.87) CCR8KCNH2CYP3A4CYP2D6ALDH1A1
SCHEMBL5410851 0.83 CCR8 (0.86) CCR8KCNH2CYP3A4CYP2D6ALDH1A1
SCHEMBL5390492 0.82 CCR8 (0.84) CCR8KCNH2CYP3A4CYP2D6TSHR
SCHEMBL5434876 0.81 CCR8 (0.82) CCR8KCNH2CYP3A4CYP2D6ALDH1A1
SCHEMBL5395119 0.80 CCR8 (0.69) CCR8KCNH2CYP3A4CYP2D6ALDH1A1
SCHEMBL5391440 0.80 CCR8 (0.79) CCR8KCNH2CYP3A4CYP2D6ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1678178-A1 NOVEL DIAZASPIROALKANES AND THEIR USE FOR TREATMENT OF CCR8 MEDIATED DISEASES AstraZeneca AB (SE) 2006-07-12 EP disclosed
WO-2005040167-A1 NOVEL DIAZASPIROALKANES AND THEIR USE FOR TREATMENT OF CCR8 MEDIATED DISEASES ASTRAZENECA AB (SE) 2005-05-06 WO disclosed