Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 11/20 | 0.60 |
| ▸ | HTR1A | P08908 | 1/20 | 0.49 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.43 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.43 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.39 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31414967 | 0.88 | TAAR1 (0.75) | TAAR1HTR1AADRA2AADRA2BADRA2C | |
| SCHEMBL10603087 | 0.83 | TAAR1 (0.63) | TAAR1HTR1AADRA2AADRA2BADRA2C | |
| SCHEMBL3749613 | 0.81 | TAAR1 (0.64) | TAAR1HTR1AADRA2AADRA2BADRA2C | |
| SCHEMBL10719843 | 0.79 | TAAR1 (0.66) | TAAR1HTR1AADRA2AADRA2BADRA2C | |
| SCHEMBL7497723 | 0.78 | HRH3 (0.34) | TAAR1 | |
| SCHEMBL535040 | 0.78 | TAAR1 (0.64) | TAAR1HTR1AADRA2AADRA2BADRA2C | |
| SCHEMBL10463711 | 0.78 | TAAR1 (0.64) | TAAR1HTR1AADRA2AADRA2BADRA2C | |
| SCHEMBL535567 | 0.78 | TAAR1 (0.64) | TAAR1HTR1AADRA2AADRA2BADRA2C | |
| SCHEMBL10997900 | 0.78 | TAAR1 (0.64) | TAAR1HTR1AADRA2AADRA2BADRA2C | |
| SCHEMBL11567295 | 0.78 | TAAR1 (0.64) | TAAR1HTR1AADRA2AADRA2BADRA2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1648875-A1 | 2-AMINOPHENYL-4-PHENYLPYRIMIDINES AS KINASE INHIBITORS | Cyclacel Limited (GB) | 2006-04-26 | — | — | EP | disclosed |
| WO-2005012262-A1 | 2-AMINOPHENYL-4-PHENYLPYRIMIDINES AS KINASE INHIBITORS | CYCLACEL LIMITED (GB) | 2005-02-10 | — | — | WO | disclosed |