SCHEMBL5779648

SCHEMBL5779648

N#C[C@@H]1C[C@H](F)CN1C(=O)CNC(CO)(CO)Cc1ccccn1

nearest known ligand 0.66

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
DPP4 P27487 18/20 0.66
PREP P48147 4/20 0.57
DPP8 Q6V1X1 3/20 0.57
DPP7 Q9UHL4 3/20 0.57
FAP Q12884 1/20 0.54
DPP9 Q86TI2 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5779937 0.80 DPP4 (1.00) DPP4PREPDPP8DPP7
SCHEMBL5777667 0.76 DPP4 (1.00) DPP4
SCHEMBL5206757 0.75 DPP4 (1.00) DPP4PREPDPP8DPP7DPP9
Hydrochloric Acid SCHEMBL5203352 0.74 DPP4 (0.98) DPP4PREPDPP8DPP7DPP9
SCHEMBL5141562 0.73 DPP4 (1.00) DPP4
SCHEMBL14619609 0.72 DPP4 (0.67) DPP4PREPDPP8DPP7DPP9
SCHEMBL4893429 0.72 DPP4 (1.00) DPP4PREPDPP8DPP7DPP9
SCHEMBL14587271 0.72 DPP4 (0.67) DPP4PREPDPP8DPP7DPP9
SCHEMBL5217616 0.72 DPP4 (0.67) DPP4PREPDPP8DPP7DPP9
Hydrochloric Acid SCHEMBL5217011 0.72 DPP4 (0.66) DPP4PREPDPP8DPP7DPP9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20060293297-A1 Cyanofluoropyrrolidine derviative TAISHO PHARMACEUTICAL CO., LTD. (JP) 2006-12-28 US disclosed
EP-1627870-A1 CYANOFLUOROPYRROLIDINE DERIVATIVE TAISHO PHARMACEUTICAL CO., LTD (JP) 2006-02-22 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060293297-A1 Cyanofluoropyrrolidine derviative DPP4, DPP3, NPY4R DPP4 1/4885PREP 618/4885DPP8 7/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.