Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 2/20 | 0.47 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.45 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.45 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.45 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.45 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.45 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.45 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.45 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.45 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 3/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5779682 | 1.00 | ATM (0.47) | ATMHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL5780653 | 1.00 | ATM (0.47) | ATMHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL8815600 | 0.89 | PTPN7 (0.38) | ATMHDAC4 | |
| SCHEMBL8817282 | 0.84 | HTT (0.55) | ATMHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL27621790 | 0.81 | ATM (0.51) | ATMHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL5779757 | 0.81 | ATM (0.47) | ATMHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL5779754 | 0.81 | ATM (0.47) | ATMHDAC3HDAC4HDAC1HDAC7 | |
| Xanthene Carboxylic Acid SCHEMBL40617 | 0.81 | ATM (0.68) | ATMHDAC3HDAC4HDAC1HDAC7 | |
| Xanthene Carboxylic Acid SCHEMBL30011680 | 0.81 | ATM (0.68) | ATMHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL8816723 | 0.81 | ATM (0.44) | ATMHDAC3HDAC4HDAC1HDAC7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100336813-C | * azoles as mGluR1 potentiators | HOFFMANN LA ROCHE (CH) | 2007-09-12 | — | — | CN | claimed |
| US-7119113-B2 | Oxazoles as mGluR1 enhancers | HOFFMANN-LA ROCHE INC. (US) | 2006-10-10 | — | — | US | claimed |
| EP-1578746-B1 | OXAZOLES AS MGLUR1 ENHANCER | HOFFMANN LA ROCHE (CH) | 2006-06-14 | — | — | EP | claimed |
| CN-1735610-A | Oxazoles as mGluR1 enhancer | HOFFMANN LA ROCHE (CH) | 2006-02-15 | — | — | CN | claimed |
| EP-1578746-A1 | OXAZOLES AS MGLUR1 ENHANCER | F. HOFFMANN-LA ROCHE AG (CH) | 2005-09-28 | — | — | EP | claimed |
| WO-2004056814-A1 | OXAZOLES AS MGLUR1 ENHANCER | F. HOFFMANN-LA ROCHE AG (CH) | 2004-07-08 | — | — | WO | claimed |
| US-20040132792-A1 | Oxazoles as mGluR 1 enhancers | HOFFMANN-LA ROCHE INC. | 2004-07-08 | — | — | US | claimed |
| CN-100336813-C | * azoles as mGluR1 potentiators | HOFFMANN LA ROCHE (CH) | 2007-09-12 | — | — | CN | disclosed |
| US-7119113-B2 | Oxazoles as mGluR1 enhancers | HOFFMANN-LA ROCHE INC. (US) | 2006-10-10 | — | — | US | disclosed |
| EP-1578746-B1 | OXAZOLES AS MGLUR1 ENHANCER | HOFFMANN LA ROCHE (CH) | 2006-06-14 | — | — | EP | disclosed |
| CN-1735610-A | Oxazoles as mGluR1 enhancer | HOFFMANN LA ROCHE (CH) | 2006-02-15 | — | — | CN | disclosed |
| EP-1578746-A1 | OXAZOLES AS MGLUR1 ENHANCER | F. HOFFMANN-LA ROCHE AG (CH) | 2005-09-28 | — | — | EP | disclosed |
| US-20040132792-A1 | Oxazoles as mGluR 1 enhancers | HOFFMANN-LA ROCHE INC. | 2004-07-08 | — | — | US | disclosed |
| WO-2004056814-A1 | OXAZOLES AS MGLUR1 ENHANCER | F. HOFFMANN-LA ROCHE AG (CH) | 2004-07-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040132792-A1 | Oxazoles as mGluR 1 enhancers | GRM1, GRM2, GRIN1 | ATM 3644/4885HDAC3 448/4885HDAC4 362/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.