Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.61 |
| ▸ | MEN1 | O00255 | 2/20 | 0.61 |
| ▸ | MAPT | P10636 | 2/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.61 |
| ▸ | APP | P05067 | 2/20 | 0.52 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.43 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.43 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.40 |
| ▸ | DRD3 | P35462 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6772626 | 0.99 | KDM4E (0.60) | KDM4EMEN1MAPTKMT2AAPP | |
| SCHEMBL5779101 | 0.92 | MAPT (0.54) | KDM4EMEN1MAPTKMT2AAPP | |
| Hydrochloric Acid SCHEMBL5780731 | 0.91 | MAPT (0.53) | KDM4EMEN1MAPTKMT2AAPP | |
| SCHEMBL6768350 | 0.87 | KMT2A (0.47) | KDM4EMEN1MAPTKMT2AAPP | |
| SCHEMBL5778531 | 0.85 | KMT2A (0.45) | KDM4EMEN1MAPTKMT2AAPP | |
| Hydrochloric Acid SCHEMBL6767983 | 0.83 | KMT2A (0.44) | KDM4EMEN1MAPTKMT2AAPP | |
| SCHEMBL6766061 | 0.80 | MEN1 (0.44) | KDM4EMEN1MAPTKMT2AAPP | |
| SCHEMBL10633512 | 0.79 | KMT2A (0.52) | KDM4EMEN1MAPTKMT2AAPP | |
| SCHEMBL10633559 | 0.79 | APP (0.52) | KDM4EMEN1MAPTKMT2AAPP | |
| SCHEMBL10633538 | 0.78 | KMT2A (0.42) | KDM4EMEN1MAPTKMT2AAPP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1153922-B1 | HETERODIAZINONE DERIVATIVES | EISAI CO LTD (JP) | 2006-04-26 | — | — | EP | claimed |
| EP-1153922-A1 | HETERODIAZINONE DERIVATIVES | Eisai Co., Ltd. (JP) | 2001-11-14 | — | — | EP | claimed |
| EP-1153922-B1 | HETERODIAZINONE DERIVATIVES | EISAI CO LTD (JP) | 2006-04-26 | — | — | EP | disclosed |
| US-6825192-B1 | NON-N-METHYL-D-ASPARTATE (NON- NMDA) EXCITATORY AMINO ACID RECEPTOR ANTAGONISTIC ACTION, FOR EXAMPLE 2-AMINO-3-HYDROXY-5-METHYL-4-ISOXAZOLE PROPIONIC ACID (AMPA) RECEPTOR ANTAGONISTIC ACTION | EISAI CO., LTD. (JP) | 2004-11-30 | — | — | US | disclosed |
| EP-1153922-A1 | HETERODIAZINONE DERIVATIVES | Eisai Co., Ltd. (JP) | 2001-11-14 | — | — | EP | disclosed |