Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.58 |
| ▸ | MAPT | P10636 | 3/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.58 |
| ▸ | GAA | P10253 | 2/20 | 0.58 |
| ▸ | NPC1 | O15118 | 2/20 | 0.55 |
| ▸ | RAB9A | P51151 | 2/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.55 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.55 |
| ▸ | RELA | Q04206 | 1/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.54 |
| ▸ | PRKCI | P41743 | 12/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7174799 | 0.95 | KDM4E (0.54) | KDM4EMAPTALDH1A1GAANPC1 | |
| SCHEMBL5776031 | 0.95 | MAPT (0.61) | KDM4EMAPTALDH1A1GAANPC1 | |
| SCHEMBL7172530 | 0.90 | MAPT (0.56) | KDM4EMAPTALDH1A1GAANPC1 | |
| SCHEMBL5780827 | 0.89 | PRKCI (0.62) | PRKCIPRKCZ | |
| SCHEMBL5777689 | 0.87 | KDM4E (0.58) | KDM4EMAPTALDH1A1GAANPC1 | |
| SCHEMBL5780464 | 0.86 | KDM4E (0.59) | KDM4EMAPTALDH1A1GAANPC1 | |
| SCHEMBL5779238 | 0.86 | PRKCI (0.46) | KDM4EMAPTALDH1A1GAASMN1; SMN2 | |
| SCHEMBL5781034 | 0.85 | KDM4E (0.62) | KDM4EMAPTALDH1A1GAANPC1 | |
| SCHEMBL5779511 | 0.85 | KDM4E (0.61) | KDM4EMAPTALDH1A1GAANPC1 | |
| SCHEMBL5116088 | 0.84 | MAPT (0.56) | KDM4EMAPTALDH1A1GAANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1685136-A1 | USE OF THIENOPYRIMIDINES | MERCK PATENT GmbH (DE) | 2006-08-02 | — | — | EP | disclosed |
| WO-2005047292-A1 | USE OF THIENOPYRIMIDINES | MERCK PATENT GMBH (DE) | 2005-05-26 | — | — | WO | disclosed |
| US-6110920-A | TREATMENT OF CARDIOVASCULAR DISORDERS AND IMPOTENCY | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2000-08-29 | — | — | US | disclosed |