Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 8/20 | 0.61 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.46 |
| ▸ | SYK | P43405 | 4/20 | 0.44 |
| ▸ | CDK4 | P11802 | 3/20 | 0.43 |
| ▸ | CDK2 | P24941 | 3/20 | 0.43 |
| ▸ | JAK2 | O60674 | 2/20 | 0.42 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.42 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.42 |
| ▸ | AURKA | O14965 | 1/20 | 0.41 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 1/20 | 0.41 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.41 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.41 |
| ▸ | ABL1 | P00519 | 1/20 | 0.40 |
| ▸ | EGFR | P00533 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5401497 | 0.88 | MEN1 (0.62) | PLK1MEN1NPC1RAB9ACDK5 | |
| SCHEMBL5399055 | 0.83 | CDK5 (0.47) | PLK1MEN1NPC1RAB9ACDK5 | |
| SCHEMBL5780608 | 0.81 | ABL1 (0.63) | PLK1MEN1CDK5KMT2ACDK5R1 | |
| SCHEMBL4735865 | 0.78 | PLK1 (0.66) | PLK1MEN1NPC1RAB9ACDK5 | |
| SCHEMBL4786087 | 0.78 | PLK1 (0.78) | PLK1MEN1NPC1RAB9ACDK5 | |
| SCHEMBL5479846 | 0.78 | PLK1 (0.66) | PLK1MEN1NPC1RAB9ACDK5 | |
| SCHEMBL4736259 | 0.76 | PLK1 (1.00) | PLK1MEN1NPC1RAB9ACDK5 | |
| SCHEMBL4735460 | 0.75 | PLK1 (0.82) | PLK1MEN1NPC1RAB9ACDK5 | |
| SCHEMBL4737520 | 0.75 | PLK1 (0.73) | PLK1MEN1NPC1RAB9ACDK5 | |
| SCHEMBL4907230 | 0.75 | PLK1 (1.00) | PLK1MEN1NPC1RAB9ACDK5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1648875-A1 | 2-AMINOPHENYL-4-PHENYLPYRIMIDINES AS KINASE INHIBITORS | Cyclacel Limited (GB) | 2006-04-26 | — | — | EP | disclosed |
| WO-2005012262-A1 | 2-AMINOPHENYL-4-PHENYLPYRIMIDINES AS KINASE INHIBITORS | CYCLACEL LIMITED (GB) | 2005-02-10 | — | — | WO | disclosed |