Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 8/20 | 0.69 |
| ▸ | KCNH2 | Q12809 | 6/20 | 0.66 |
| ▸ | HTR2C | P28335 | 5/20 | 0.66 |
| ▸ | DRD2 | P14416 | 4/20 | 0.53 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.49 |
| ▸ | DRD3 | P35462 | 5/20 | 0.48 |
| ▸ | HTR6 | P50406 | 4/20 | 0.48 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.43 |
| ▸ | SPR | P35270 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23423396 | 0.85 | HTR2A (0.51) | HTR2AKCNH2HTR2CDRD2HTR6 | |
| SCHEMBL16963836 | 0.83 | HTR2A (0.69) | HTR2AKCNH2HTR2CDRD2SPR | |
| SCHEMBL15232716 | 0.81 | HTR2A (0.51) | HTR2AKCNH2HTR2CDRD2HRH3 | |
| SCHEMBL5704984 | 0.81 | HTR2A (0.62) | HTR2AKCNH2HTR2CDRD2HTR6 | |
| SCHEMBL14242442 | 0.78 | BLM (0.55) | HTR2AKCNH2HTR2CDRD2SPR | |
| SCHEMBL2048495 | 0.78 | HTR2A (0.59) | HTR2AKCNH2HTR2CDRD2HTR6 | |
| SCHEMBL20069159 | 0.78 | HTR2A (0.50) | HTR2AKCNH2HTR2CHRH3 | |
| SCHEMBL3025333 | 0.77 | HTR2A (0.61) | HTR2AKCNH2HTR2CDRD2SPR | |
| SCHEMBL3025337 | 0.77 | HTR2A (0.61) | HTR2AKCNH2HTR2CDRD2SPR | |
| SCHEMBL16963838 | 0.77 | HTR2A (0.56) | HTR2AKCNH2HTR2CDRD2SPR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1641756-A1 | 4-ARYLSULPHONYLPIPERIDINE DERIVATIVES FOR ANTAGONISM OF THE 5-HT2A RECEPTOR | MERCK SHARP & DOHME LTD. (GB) | 2006-04-05 | — | — | EP | disclosed |
| WO-2004101518-A1 | 4-ARYLSULPHONYLPIPERIDINE DERIVATIVES FOR ANTAGONISM OF THE 5-HT2A RECEPTOR | MERCK SHARP & DOHME LIMITED (GB) | 2004-11-25 | — | — | WO | disclosed |