Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 16/20 | 0.56 |
| ▸ | ERBB2 | P04626 | 16/20 | 0.55 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5629707 | 0.95 | EGFR (0.60) | EGFRERBB2KCNH2 | |
| SCHEMBL5628707 | 0.89 | EGFR (0.53) | EGFRERBB2KCNH2 | |
| SCHEMBL5630035 | 0.89 | EGFR (0.58) | EGFRERBB2KCNH2 | |
| SCHEMBL5629553 | 0.88 | EGFR (0.58) | EGFRERBB2KCNH2 | |
| SCHEMBL5629571 | 0.88 | EGFR (0.54) | EGFRERBB2KCNH2 | |
| SCHEMBL5628581 | 0.88 | ERBB2 (0.53) | EGFRERBB2KCNH2 | |
| SCHEMBL5632383 | 0.88 | EGFR (0.60) | EGFRERBB2KCNH2 | |
| SCHEMBL5774457 | 0.88 | EGFR (0.63) | EGFRERBB2 | |
| SCHEMBL5630761 | 0.87 | EGFR (0.56) | EGFRERBB2KCNH2 | |
| SCHEMBL5629308 | 0.87 | EGFR (0.55) | EGFRERBB2KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7238701-B2 | Substituted tetrahydrobenzothienopyrimidinamine compounds useful for treating hyper-proliferative disorders | BAYER PHARMACEUTICALS CORPORATION (US) | 2007-07-03 | — | — | US | disclosed |
| US-7238701-B2 | Substituted tetrahydrobenzothienopyrimidinamine compounds useful for treating hyper-proliferative disorders | BAYER PHARMACEUTICALS CORPORATION (US) | 2007-07-03 | — | — | US | disclosed |
| EP-1651652-B1 | SUBSTITUTED TETRAHYDROBENZOTHIENOPYRIMIDINAMINE COMPOUNDS USEFUL FOR TREATING HYPER-PROLIFERATIVE DISORDERS | BAYER PHARMACEUTICALS CORP (US) | 2006-12-27 | — | — | EP | disclosed |