Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 11/20 | 0.47 |
| ▸ | DYRK1A | Q13627 | 6/20 | 0.35 |
| ▸ | DYRK2 | Q92630 | 6/20 | 0.35 |
| ▸ | CLK1 | P49759 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | CDK9 | P50750 | 2/20 | 0.33 |
| ▸ | FABP4 | P15090 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4530604 | 0.87 | MAPK14 (0.51) | MAPK14DYRK1ADYRK2CLK1ALDH1A1 | |
| SCHEMBL3992817 | 0.84 | MAPK14 (0.66) | MAPK14DYRK1ADYRK2CLK1ALDH1A1 | |
| SCHEMBL29593607 | 0.84 | MAPK14 (0.66) | MAPK14DYRK1ADYRK2CLK1ALDH1A1 | |
| SCHEMBL4300769 | 0.82 | MAPK14 (0.47) | MAPK14DYRK1ADYRK2CLK1ALDH1A1 | |
| SCHEMBL4300771 | 0.82 | MAPK14 (0.47) | MAPK14DYRK1ADYRK2CLK1ALDH1A1 | |
| SCHEMBL29594245 | 0.73 | MAPK14 (0.54) | MAPK14DYRK1ADYRK2CLK1ALDH1A1 | |
| SCHEMBL4069800 | 0.73 | MAPK14 (0.54) | MAPK14DYRK1ADYRK2CLK1ALDH1A1 | |
| SCHEMBL3997550 | 0.73 | MAPK14 (0.40) | MAPK14DYRK1ADYRK2CLK1ALDH1A1 | |
| SCHEMBL3997548 | 0.73 | MAPK14 (0.40) | MAPK14DYRK1ADYRK2CLK1ALDH1A1 | |
| SCHEMBL4528981 | 0.68 | MAPK14 (0.40) | MAPK14DYRK1ADYRK2CLK1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1713805-A1 | KINASE INHIBITORS | ELI LILLY AND COMPANY (US) | 2006-10-25 | — | — | EP | disclosed |
| WO-2005075478-A1 | KINASE INHIBITORS | ELI LILLY AND COMPANY (US) | 2005-08-18 | — | — | WO | disclosed |