Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.50 |
| ▸ | NPC1 | O15118 | 6/20 | 0.50 |
| ▸ | RAB9A | P51151 | 6/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.50 |
| ▸ | MAPT | P10636 | 4/20 | 0.50 |
| ▸ | GAA | P10253 | 4/20 | 0.50 |
| ▸ | MEN1 | O00255 | 3/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.50 |
| ▸ | ILK | Q13418 | 7/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | GLA | P06280 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | APP | P05067 | 1/20 | 0.43 |
| ▸ | MMP9 | P14780 | 1/20 | 0.43 |
| ▸ | MMP8 | P22894 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5101469 | 0.75 | KDM4E (0.54) | KDM4ENPC1RAB9AALDH1A1MAPT | |
| SCHEMBL231307 | 0.75 | KDM4E (0.75) | KDM4ENPC1RAB9AALDH1A1MAPT | |
| SCHEMBL543407 | 0.74 | NPC1 (0.45) | KDM4ENPC1RAB9AALDH1A1MAPT | |
| SCHEMBL3398344 | 0.73 | KDM4E (0.51) | KDM4ENPC1RAB9AALDH1A1MAPT | |
| SCHEMBL12854008 | 0.73 | KDM4E (0.72) | KDM4ENPC1RAB9AALDH1A1MAPT | |
| SCHEMBL1812287 | 0.72 | NPC1 (0.54) | KDM4ENPC1RAB9AALDH1A1MAPT | |
| SCHEMBL1323935 | 0.72 | KDM4E (0.50) | KDM4ENPC1RAB9AALDH1A1MAPT | |
| SCHEMBL1770412 | 0.72 | KDM4E (0.33) | KDM4ENPC1RAB9AALDH1A1MAPT | |
| SCHEMBL2225061 | 0.71 | KDM4E (0.64) | KDM4ENPC1RAB9AALDH1A1MAPT | |
| SCHEMBL30689066 | 0.71 | KDM4E (0.64) | KDM4ENPC1RAB9AALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2909189-A1 | HETEROARYL LINKED QUINOLINYL MODULATORS OF RORyt | Janssen Pharmaceutica, N.V. (BE) | 2015-08-26 | — | — | EP | claimed |
| WO-2014062655-A1 | HETEROARYL LINKED QUINOLINYL MODULATORS OF RORyt | JANSSEN PHARMACEUTICA NV (BE) | 2014-04-24 | — | — | WO | claimed |
| EP-1638945-A1 | HETEROCYCLICALLY SUBSTITUTED PENTANOL DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF, AND USE THEREOF AS ANTI-INFLAMMATORY AGENTS | Schering Aktiengesellschaft (DE) | 2006-03-29 | — | — | EP | claimed |
| WO-2005003098-A1 | HETEROCYCLICALLY SUBSTITUTED PENTANOL DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF, AND USE THEREOF AS ANTI-INFLAMMATORY AGENTS | SCHERING AKTIENGESELLSCHAFT (DE) | 2005-01-13 | — | — | WO | claimed |
| WO-2016065583-A1 | OXAZOLE OREXIN RECEPTOR ANTAGONISTS | MERCK SHARP & DOHME CORP. (US) | 2016-05-06 | — | — | WO | disclosed |
| EP-2909192-A1 | METHYLENE LINKED QUINOLINYL MODULATORS OF ROR-GAMMA-T | Janssen Pharmaceutica, N.V. (BE) | 2015-08-26 | — | — | EP | disclosed |
| WO-2014062658-A1 | METHYLENE LINKED QUINOLINYL MODULATORS OF ROR-GAMMA-T | JANSSEN PHARMACEUTICA NV (BE) | 2014-04-24 | — | — | WO | disclosed |