Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 20/20 | 0.70 |
| ▸ | PPARA | Q07869 | 20/20 | 0.70 |
| ▸ | PPARD | Q03181 | 16/20 | 0.70 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5781292 | 0.94 | PPARG (0.79) | PPARGPPARAPPARD | |
| SCHEMBL5783169 | 0.88 | PPARG (0.88) | PPARGPPARAPPARD | |
| SCHEMBL5782098 | 0.88 | PPARG (0.71) | PPARGPPARAPPARD | |
| SCHEMBL5783214 | 0.85 | PPARG (0.68) | PPARGPPARAPPARD | |
| SCHEMBL5780224 | 0.83 | PPARG (0.68) | PPARGPPARAPPARD | |
| SCHEMBL5015839 | 0.82 | PPARG (0.69) | PPARGPPARAPPARD | |
| SCHEMBL5779351 | 0.82 | PPARG (1.00) | PPARGPPARAPPARD | |
| SCHEMBL5780863 | 0.82 | PPARG (1.00) | PPARGPPARAPPARD | |
| SCHEMBL5780682 | 0.82 | PPARG (0.80) | PPARGPPARAPPARD | |
| SCHEMBL5780869 | 0.82 | PPARG (1.00) | PPARGPPARAPPARD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1539746-B1 | N-SUBSTITUTED-1H-INDOL-5-PROPIONIC ACID COMPOUNDS AS PPAR AGONISTS USEFUL FOR THE TREATMENT OF DIABETES | HOFFMANN LA ROCHE (CH) | 2006-11-15 | — | — | EP | disclosed |
| EP-1539746-A1 | N-SUBSTITUTED-1H-INDOL-5-PROPIONIC ACID COMPOUNDS AS PPAR AGONISTS USEFUL FOR THE TREATMENT OF DIABETES | F. HOFFMANN-LA ROCHE AG (CH) | 2005-06-15 | — | — | EP | disclosed |
| US-6890947-B2 | Indolyl derivatives | HOFFMANN-LA ROCHE INC. (US) | 2005-05-10 | — | — | US | disclosed |
| WO-2004024726-A1 | N-SUBSTITUTED-1H-INDOL-5-PROPIONIC ACID COMPOUNDS AS PPAR AGONISTS USEFUL FOR THE TREATMENT OF DIABETES | F. HOFFMANN-LA ROCHE AG (CH) | 2004-03-25 | — | — | WO | disclosed |