Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 3/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.41 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.41 |
| ▸ | GRM3 | Q14832 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | APLNR | P35414 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | BLM | P54132 | 2/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | GRIA1 | P42261 | 3/20 | 0.35 |
| ▸ | GRIA2 | P42262 | 3/20 | 0.35 |
| ▸ | GRIA3 | P42263 | 3/20 | 0.35 |
| ▸ | GRIA4 | P48058 | 3/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5781957 | 1.00 | CYP1A2 (0.41) | CYP1A2ALOX15GRM2GRM3HTT | |
| Trifluoroacetic Acid SCHEMBL17476043 | 0.89 | GRM2 (0.35) | CYP1A2ALOX15GRM2GRM3HTT | |
| SCHEMBL23440430 | 0.82 | CYP1A2 (0.40) | CYP1A2ALOX15GRM2GRM3HTT | |
| SCHEMBL5778614 | 0.82 | GLI1 (0.34) | CYP1A2ALOX15GRM2GRM3 | |
| SCHEMBL23440432 | 0.82 | CYP1A2 (0.40) | CYP1A2ALOX15GRM2GRM3HTT | |
| SCHEMBL5778622 | 0.82 | GLI1 (0.34) | CYP1A2ALOX15GRM2GRM3 | |
| SCHEMBL25922441 | 0.79 | KMT2A (0.39) | CYP1A2ALOX15CYP2D6CYP2C19TSHR | |
| SCHEMBL18154922 | 0.78 | CYP1A2 (0.53) | CYP1A2ALOX15GRM2GRM3HTT | |
| SCHEMBL556206 | 0.78 | CYP1A2 (0.53) | CYP1A2ALOX15GRM2GRM3HTT | |
| SCHEMBL556207 | 0.78 | CYP1A2 (0.53) | CYP1A2ALOX15GRM2GRM3HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1539747-B1 | N-AROYL CYCLIC AMINES AS OREXIN RECEPTOR ANTAGONISTS | GLAXO GROUP LTD (GB) | 2006-11-02 | — | — | EP | disclosed |
| US-20060040937-A1 | N-aroyl cyclic amines as orexin receptor antagonists | GLAXO GROUP LIMITED (GB) | 2006-02-23 | — | — | US | disclosed |
| EP-1539747-A1 | N-AROYL CYCLIC AMINES AS OREXIN RECEPTOR ANTAGONISTS | GLAXO GROUP LIMITED (GB) | 2005-06-15 | — | — | EP | disclosed |
| WO-2004026866-A1 | N-AROYL CYCLIC AMINES AS OREXIN RECEPTOR ANTAGONISTS | GLAXO GROUP LIMITED (GB) | 2004-04-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060040937-A1 | N-aroyl cyclic amines as orexin receptor antagonists | HCRTR2, HCRTR1, NTSR2 | CYP1A2 1191/4885ALOX15 1076/4885GRM2 292/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.