Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARA | Q07869 | 14/20 | 0.70 |
| ▸ | PPARD | Q03181 | 13/20 | 0.70 |
| ▸ | PPARG | P37231 | 3/20 | 0.54 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.42 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.39 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.39 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.39 |
| ▸ | ITGAV | P06756 | 1/20 | 0.39 |
| ▸ | ITGA5 | P08648 | 1/20 | 0.39 |
| ▸ | ITGB5 | P18084 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5639570 | 0.97 | PPARA (0.69) | PPARAPPARDPPARGFFAR1ITGB3 | |
| SCHEMBL5639234 | 0.94 | PPARA (0.78) | PPARAPPARDPPARGSMPD1ITGB3 | |
| SCHEMBL5802559 | 0.85 | PPARA (0.85) | PPARAPPARDPPARG | |
| SCHEMBL5643122 | 0.84 | PPARD (0.60) | PPARAPPARDPPARGKDM4EMEN1 | |
| SCHEMBL5639602 | 0.84 | PPARA (0.72) | PPARAPPARDPPARGFFAR1 | |
| SCHEMBL5639088 | 0.83 | PPARD (1.00) | PPARAPPARDPPARGKDM4EMEN1 | |
| SCHEMBL5640225 | 0.82 | PPARA (0.67) | PPARAPPARDPPARGITGB3ITGB1 | |
| SCHEMBL5639634 | 0.82 | PPARD (0.69) | PPARAPPARDPPARGFFAR1MAPT | |
| SCHEMBL5641428 | 0.81 | PPARA (0.77) | PPARAPPARDPPARGITGB3ITGB1 | |
| SCHEMBL5638536 | 0.81 | PPARA (0.81) | PPARAPPARDPPARGSMPD1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1620086-A1 | COMPOUNDS THAT MODULATE PPAR ACTIVITY AND METHODS OF PREPARATION | Warner-Lambert Company LLC (US) | 2006-02-01 | — | — | EP | claimed |
| WO-2004091604-A1 | COMPOUNDS THAT MODULATE PPAR ACTIVITY AND METHODS OF PREPARATION | WARNER-LAMBERT COMPANY LLC (US) | 2004-10-28 | — | — | WO | claimed |