SCHEMBL5784192

SCHEMBL5784192

O=C(NN1CCCCC1)c1nc(-c2ccc(Cl)cc2)c(-c2ccc(Cl)cc2)nc1C1CCCCC1

nearest known ligand 0.58

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
CNR1 P21554 13/20 0.58
CNR2 P34972 6/20 0.54

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4682588 0.82 CNR1 (0.65) CNR1CNR2
SCHEMBL4684802 0.81 CNR1 (0.55) CNR1CNR2
SCHEMBL6823078 0.80 CNR1 (0.62) CNR1CNR2
SCHEMBL4681525 0.79 CNR1 (0.61) CNR1CNR2
SCHEMBL4684199 0.79 CNR1 (0.53) CNR1CNR2
SCHEMBL4677627 0.78 CNR1 (0.52) CNR1CNR2
SCHEMBL4680736 0.77 CNR1 (0.58) CNR1CNR2
SCHEMBL4676951 0.77 CNR1 (0.59) CNR1CNR2
SCHEMBL4681746 0.77 CNR1 (0.58) CNR1CNR2
SCHEMBL4680422 0.77 CNR1 (0.59) CNR1CNR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1638953-A1 3-SUBSTITUTED 5,6-DIARYL-PYRAZINE-2-CARBOXAMIDE AND -2-SULFONAMIDE DERIVATIVES AS CB1 MODULATORS AstraZeneca AB (SE) 2006-03-29 EP claimed
WO-2004111034-A1 3-SUBSTITUTED 5,6-DIARYL-PYRAZINE-2-CARBOXAMIDE AND -2-SULFONAMIDE DERIVATIVES AS CB1 MODULATORS ASTRAZENECA AB (SE) 2004-12-23 WO claimed