Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTK2 | Q05397 | 12/20 | 0.57 |
| ▸ | PTK2B | Q14289 | 9/20 | 0.54 |
| ▸ | KIT | P10721 | 4/20 | 0.51 |
| ▸ | FLT3 | P36888 | 4/20 | 0.51 |
| ▸ | AURKA | O14965 | 1/20 | 0.51 |
| ▸ | EGFR | P00533 | 1/20 | 0.51 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.51 |
| ▸ | CDK1 | P06493 | 1/20 | 0.51 |
| ▸ | IGF1R | P08069 | 1/20 | 0.51 |
| ▸ | EPHA1 | P21709 | 1/20 | 0.51 |
| ▸ | CDK2 | P24941 | 1/20 | 0.51 |
| ▸ | BMX | P51813 | 1/20 | 0.51 |
| ▸ | JAK3 | P52333 | 1/20 | 0.51 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.51 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.51 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.51 |
| ▸ | SYK | P43405 | 2/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.49 |
| ▸ | ULK1 | O75385 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12174633 | 1.00 | PTK2 (0.57) | PTK2PTK2BKITFLT3AURKA | |
| SCHEMBL578672 | 1.00 | PTK2 (0.57) | PTK2PTK2BKITFLT3AURKA | |
| SCHEMBL578714 | 1.00 | PTK2 (0.57) | PTK2PTK2BKITFLT3AURKA | |
| SCHEMBL13808220 | 0.98 | PTK2 (0.55) | PTK2PTK2BKITFLT3AURKA | |
| SCHEMBL4280145 | 0.96 | PTK2 (0.54) | PTK2PTK2BKITFLT3AURKA | |
| SCHEMBL4280140 | 0.96 | PTK2 (0.54) | PTK2PTK2BKITFLT3AURKA | |
| SCHEMBL578783 | 0.96 | PTK2 (0.55) | PTK2PTK2BKITFLT3AURKA | |
| SCHEMBL578782 | 0.96 | PTK2 (0.55) | PTK2PTK2BKITFLT3AURKA | |
| SCHEMBL4288959 | 0.94 | PTK2 (0.56) | PTK2PTK2BKITFLT3AURKA | |
| SCHEMBL4288963 | 0.94 | PTK2 (0.56) | PTK2PTK2BKITFLT3AURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2027107-B1 | 2, 4 -DIAMINO PYRIMIDINES AS CELL CYCLE KINASE INHIBITORS | BOEHRINGER INGELHEIM INT (DE) | 2012-02-15 | — | — | EP | claimed |
| US-20210213037-A1 | METHODS FOR TREATING FIBROSIS | CHILDREN'S HOSPITAL MEDICAL CENTER (US) | 2021-07-15 | — | — | US | disclosed |
| EP-2027107-B1 | 2, 4 -DIAMINO PYRIMIDINES AS CELL CYCLE KINASE INHIBITORS | BOEHRINGER INGELHEIM INT (DE) | 2012-02-15 | — | — | EP | disclosed |