Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 16/20 | 0.67 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | MTOR | P42345 | 1/20 | 0.42 |
| ▸ | GPR52 | Q9Y2T5 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5458918 | 0.91 | CNR2 (0.72) | CNR2POLBCYP1A2CYP2C9CYP2C19 | |
| SCHEMBL5488182 | 0.91 | CNR2 (0.78) | CNR2POLBCYP1A2CYP2C9CYP2C19 | |
| SCHEMBL5452949 | 0.88 | CNR2 (0.84) | CNR2POLBCYP1A2CYP2C9CYP2C19 | |
| SCHEMBL5789075 | 0.86 | CNR2 (0.56) | CNR2POLBCYP1A2CYP2C9CYP2C19 | |
| SCHEMBL5466603 | 0.86 | CNR2 (0.60) | CNR2POLBCYP1A2CYP2C9CYP2C19 | |
| SCHEMBL5466608 | 0.83 | CNR2 (0.52) | CNR2POLBCYP1A2CYP2C9CYP2C19 | |
| SCHEMBL5447794 | 0.81 | CNR2 (0.63) | CNR2POLBGPR52LMNA | |
| SCHEMBL5216312 | 0.81 | CNR2 (0.65) | CNR2 | |
| SCHEMBL5459863 | 0.80 | CNR2 (0.81) | CNR2POLBCYP1A2CYP2C9CYP2C19 | |
| SCHEMBL5448657 | 0.80 | CNR2 (1.00) | CNR2POLBCYP1A2CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1562907-B1 | PYRIDINE DERIVATIVES AS CB2 RECEPTOR MODULATORS | GLAXO GROUP LTD (GB) | 2006-11-15 | — | — | EP | claimed |
| EP-1562907-B1 | PYRIDINE DERIVATIVES AS CB2 RECEPTOR MODULATORS | GLAXO GROUP LTD (GB) | 2006-11-15 | — | — | EP | disclosed |