Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNF | P01375 | 2/20 | 0.62 |
| ▸ | NOD1 | Q9Y239 | 2/20 | 0.62 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.59 |
| ▸ | POLB | P06746 | 1/20 | 0.59 |
| ▸ | PKM | P14618 | 1/20 | 0.59 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.59 |
| ▸ | PIP4K2C | Q8TBX8 | 2/20 | 0.54 |
| ▸ | EGFR | P00533 | 2/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.46 |
| ▸ | CCNC | P24863 | 1/20 | 0.44 |
| ▸ | CDK8 | P49336 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | GFER | P55789 | 1/20 | 0.43 |
| ▸ | HTR7 | P34969 | 2/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27640124 | 0.86 | TNF (0.69) | TNFNOD1MAPK1SMN1; SMN2ALDH1A1 | |
| SCHEMBL2369141 | 0.81 | TNF (0.73) | TNFNOD1MAPK1SMN1; SMN2ALDH1A1 | |
| SCHEMBL2369055 | 0.77 | MAPK1 (0.78) | TNFNOD1MAPK1SMN1; SMN2ALDH1A1 | |
| SCHEMBL2369019 | 0.77 | MAPK1 (1.00) | TNFNOD1MAPK1SMN1; SMN2ALDH1A1 | |
| SCHEMBL3387956 | 0.76 | TNF (0.83) | TNFNOD1MAPK1SMN1; SMN2ALDH1A1 | |
| SCHEMBL2368708 | 0.76 | TNF (0.83) | TNFNOD1MAPK1SMN1; SMN2ALDH1A1 | |
| SCHEMBL3384909 | 0.76 | TNF (0.59) | TNFNOD1MAPK1SMN1; SMN2ALDH1A1 | |
| SCHEMBL3386302 | 0.75 | TNF (0.78) | TNFNOD1MAPK1SMN1; SMN2ALDH1A1 | |
| SCHEMBL3383483 | 0.75 | TNF (0.70) | TNFNOD1MAPK1SMN1; SMN2ALDH1A1 | |
| SCHEMBL2368569 | 0.74 | TNF (0.83) | TNFNOD1MAPK1SMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1641803-A1 | THIENOPYRIMIDINE DERIVATIVES AS POTASSIUM CHANNEL INHIBITORS | Xention Discovery Limited (GB) | 2006-04-05 | — | — | EP | disclosed |
| WO-2004111057-A1 | THIENOPYRIMIDINE DERIVATIVES AS POTASSIUM CHANNEL INHIBITORS | XENTION DISCOVERY LIMITED (GB) | 2004-12-23 | — | — | WO | disclosed |