Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 20/20 | 0.68 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6291854 | 0.91 | PDE5A (0.64) | PDE5A | |
| SCHEMBL9928813 | 0.90 | PDE5A (0.73) | PDE5A | |
| SCHEMBL5789197 | 0.90 | PDE5A (0.73) | PDE5A | |
| SCHEMBL9928823 | 0.87 | PDE5A (0.63) | PDE5A | |
| SCHEMBL9928821 | 0.87 | PDE5A (0.63) | PDE5A | |
| SCHEMBL6221521 | 0.87 | PDE5A (0.75) | PDE5A | |
| SCHEMBL9928773 | 0.87 | PDE5A (0.65) | PDE5A | |
| SCHEMBL5790417 | 0.87 | PDE5A (0.65) | PDE5A | |
| SCHEMBL5789759 | 0.87 | PDE5A (0.69) | PDE5A | |
| SCHEMBL9928817 | 0.86 | PDE5A (0.59) | PDE5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1360186-B1 | CARBOLINE DERIVATIVES | LILLY ICOS LLC (US) | 2006-11-22 | — | — | EP | claimed |
| US-7122554-B2 | Carboline derivatives | LILLY ICOS LLC. (US) | 2006-10-17 | — | — | US | claimed |
| US-20040116458-A1 | Chemical compounds | LILLY ICOS LLC, A DELAWARE CORPORATION | 2004-06-17 | — | — | US | claimed |
| EP-1360186-B1 | CARBOLINE DERIVATIVES | LILLY ICOS LLC (US) | 2006-11-22 | — | — | EP | disclosed |
| US-7122554-B2 | Carboline derivatives | LILLY ICOS LLC. (US) | 2006-10-17 | — | — | US | disclosed |
| US-20040116458-A1 | Chemical compounds | LILLY ICOS LLC, A DELAWARE CORPORATION | 2004-06-17 | — | — | US | disclosed |