SCHEMBL578997

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

	Compound	similarity	top predicted	shared targets
	SCHEMBL12438378	0.90	JAK3 (0.52)	JAK3AURKAEGFRNTRK1CDK1
	SCHEMBL10148425	0.89	JAK3 (0.54)	JAK3AURKAEGFRNTRK1CDK1
	SCHEMBL10149268	0.87	SYK (0.52)	JAK3JAK2JAK1SYKPTK2
	SCHEMBL2324528	0.87	JAK2 (0.51)	AURKAIGF1RJAK2JAK1SYK
	Bicarbonate SCHEMBL579108	0.83	FLT3 (0.64)	JAK3AURKAEGFRNTRK1CDK1
	Bicarbonate SCHEMBL579262	0.83	KIT (0.64)	JAK3AURKAEGFRNTRK1CDK1
	SCHEMBL13808086	0.83	FLT3 (0.61)	JAK3AURKAEGFRNTRK1CDK1
	SCHEMBL579261	0.83	FLT3 (0.61)	JAK3AURKAEGFRNTRK1CDK1
	SCHEMBL578790	0.82	FLT3 (0.55)	JAK3AURKAEGFRNTRK1CDK1
	SCHEMBL13808085	0.82	FLT3 (0.55)	JAK3AURKAEGFRNTRK1CDK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.