Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 6/20 | 0.57 |
| ▸ | HDAC3 | O15379 | 6/20 | 0.57 |
| ▸ | HDAC1 | Q13547 | 6/20 | 0.57 |
| ▸ | HDAC4 | P56524 | 5/20 | 0.57 |
| ▸ | HDAC7 | Q8WUI4 | 5/20 | 0.57 |
| ▸ | HDAC2 | Q92769 | 5/20 | 0.57 |
| ▸ | HDAC10 | Q969S8 | 5/20 | 0.57 |
| ▸ | HDAC11 | Q96DB2 | 5/20 | 0.57 |
| ▸ | HDAC8 | Q9BY41 | 5/20 | 0.57 |
| ▸ | HDAC9 | Q9UKV0 | 5/20 | 0.57 |
| ▸ | HDAC5 | Q9UQL6 | 5/20 | 0.57 |
| ▸ | ADRA2A | P08913 | 5/20 | 0.51 |
| ▸ | HTR2B | P41595 | 3/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.51 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.51 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL442963 | 0.77 | HDAC1 (0.64) | HDAC6HDAC3HDAC1HDAC4HDAC7 | |
| SCHEMBL21375731 | 0.76 | HDAC1 (0.74) | HDAC6HDAC3HDAC1HDAC4HDAC7 | |
| SCHEMBL11441208 | 0.76 | HDAC3 (0.69) | HDAC6HDAC3HDAC1HDAC4HDAC7 | |
| SCHEMBL22121431 | 0.76 | HDAC3 (0.69) | HDAC6HDAC3HDAC1HDAC4HDAC7 | |
| SCHEMBL1192990 | 0.76 | HDAC1 (0.74) | HDAC6HDAC3HDAC1HDAC4HDAC7 | |
| SCHEMBL7386781 | 0.74 | PARP1 (0.53) | HDAC6ADRA2AHTR2BMEN1LMNA | |
| SCHEMBL11220445 | 0.73 | HDAC1 (0.74) | HDAC6HDAC3HDAC1HDAC4HDAC7 | |
| SCHEMBL12422572 | 0.73 | HDAC1 (0.74) | HDAC6HDAC3HDAC1HDAC4HDAC7 | |
| SCHEMBL3247728 | 0.73 | HDAC1 (0.74) | HDAC6HDAC3HDAC1HDAC4HDAC7 | |
| SCHEMBL28444240 | 0.73 | HDAC1 (0.74) | HDAC6HDAC3HDAC1HDAC4HDAC7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1611088-A2 | HYDROXAMATES AS THERAPEUTIC AGENTS | AXYS PHARMACEUTICALS, INC. (US) | 2006-01-04 | — | — | EP | claimed |
| WO-2004092115-A2 | HYDROXAMATES AS THERAPEUTIC AGENTS | AXYS PHARMACEUTICALS INC. (US) | 2004-10-28 | — | — | WO | claimed |