Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTK2 | Q05397 | 13/20 | 0.60 |
| ▸ | PTK2B | Q14289 | 10/20 | 0.53 |
| ▸ | FLT3 | P36888 | 3/20 | 0.51 |
| ▸ | AURKA | O14965 | 1/20 | 0.51 |
| ▸ | EGFR | P00533 | 1/20 | 0.51 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.51 |
| ▸ | CDK1 | P06493 | 1/20 | 0.51 |
| ▸ | IGF1R | P08069 | 1/20 | 0.51 |
| ▸ | KIT | P10721 | 1/20 | 0.51 |
| ▸ | EPHA1 | P21709 | 1/20 | 0.51 |
| ▸ | CDK2 | P24941 | 1/20 | 0.51 |
| ▸ | BMX | P51813 | 1/20 | 0.51 |
| ▸ | JAK3 | P52333 | 1/20 | 0.51 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.51 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.51 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.51 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.48 |
| ▸ | SYK | P43405 | 2/20 | 0.48 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL579014 | 1.00 | PTK2 (0.60) | PTK2PTK2BFLT3AURKAEGFR | |
| SCHEMBL4195375 | 0.99 | PTK2 (0.58) | PTK2PTK2BFLT3AURKAEGFR | |
| SCHEMBL578904 | 0.94 | PTK2 (0.57) | PTK2PTK2BFLT3AURKAEGFR | |
| SCHEMBL579114 | 0.93 | PTK2 (0.57) | PTK2PTK2BFLT3AURKAEGFR | |
| SCHEMBL579144 | 0.93 | PTK2 (0.57) | PTK2PTK2BFLT3AURKAEGFR | |
| SCHEMBL13808111 | 0.92 | PTK2 (0.56) | PTK2PTK2BFLT3AURKAEGFR | |
| SCHEMBL13808235 | 0.92 | PTK2 (0.56) | PTK2PTK2BFLT3AURKAEGFR | |
| SCHEMBL13808261 | 0.92 | PTK2 (0.56) | PTK2PTK2BFLT3AURKAEGFR | |
| SCHEMBL13808262 | 0.92 | PTK2 (0.58) | PTK2PTK2BFLT3AURKAEGFR | |
| SCHEMBL578813 | 0.92 | PTK2 (0.56) | PTK2PTK2BFLT3AURKAEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2027107-B1 | 2, 4 -DIAMINO PYRIMIDINES AS CELL CYCLE KINASE INHIBITORS | BOEHRINGER INGELHEIM INT (DE) | 2012-02-15 | — | — | EP | claimed |
| EP-2027107-B1 | 2, 4 -DIAMINO PYRIMIDINES AS CELL CYCLE KINASE INHIBITORS | BOEHRINGER INGELHEIM INT (DE) | 2012-02-15 | — | — | EP | disclosed |