SCHEMBL5790486

SCHEMBL5790486

O=C(NS(=O)(=O)c1ccc(NC2(CSc3ccccc3)CCN(C(=O)O)CC2)c([N+](=O)[O-])c1)c1ccc(N2CCC3(CCCC3)CC2)cc1

nearest known ligand 0.61

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
BCL2L1 Q07817 20/20 0.61
BCL2 P10415 15/20 0.61
ALB P02768 1/20 0.55
BCL2L2 Q92843 1/20 0.55

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2945513 0.92 BCL2L1 (0.65) BCL2L1BCL2ALBBCL2L2
SCHEMBL2950293 0.91 BCL2L1 (0.68) BCL2L1BCL2ALBBCL2L2
SCHEMBL2949152 0.84 BCL2L1 (0.84) BCL2L1BCL2
SCHEMBL2949777 0.82 BCL2L1 (0.86) BCL2L1BCL2ALBBCL2L2
SCHEMBL1540911 0.82 BCL2L1 (0.67) BCL2L1BCL2BCL2L2
SCHEMBL2948205 0.82 BCL2L1 (0.72) BCL2L1BCL2ALBBCL2L2
SCHEMBL1541432 0.81 BCL2L1 (0.72) BCL2L1BCL2
SCHEMBL2945370 0.80 BCL2L1 (0.64) BCL2L1BCL2ALBBCL2L2
SCHEMBL2943774 0.80 BCL2L1 (0.80) BCL2L1BCL2
SCHEMBL2943803 0.80 BCL2L1 (0.66) BCL2L1BCL2ALBBCL2L2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1318978-B1 N-ACYLSULFONAMIDE APOPTOSIS PROMOTERS ABBOTT LAB (US) 2006-02-08 EP disclosed