Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.78 |
| ▸ | KCNH2 | Q12809 | 6/20 | 0.78 |
| ▸ | HPGD | P15428 | 6/20 | 0.78 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.78 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.78 |
| ▸ | POLB | P06746 | 1/20 | 0.78 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.78 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.78 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.78 |
| ▸ | CLK2 | P49760 | 1/20 | 0.78 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.78 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.78 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.63 |
| ▸ | MEN1 | O00255 | 2/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.58 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13841370 | 0.93 | KDM4E (0.67) | KDM4EKCNH2HPGDALDH1A1HSD17B10 | |
| Gatifloxacin SCHEMBL3339392 | 0.89 | KDM4E (0.98) | KDM4EKCNH2HPGDALDH1A1HSD17B10 | |
| (S)-Gatifloxacin SCHEMBL3339394 | 0.89 | KDM4E (0.98) | KDM4EKCNH2HPGDALDH1A1HSD17B10 | |
| SCHEMBL3958402 | 0.88 | KCNH2 (0.66) | KDM4EKCNH2HPGDALDH1A1HSD17B10 | |
| Gatifloxacin SCHEMBL2224369 | 0.88 | KDM4E (1.00) | KDM4EKCNH2HPGDALDH1A1HSD17B10 | |
| Gatifloxacin SCHEMBL22591 | 0.88 | KDM4E (1.00) | KDM4EKCNH2HPGDALDH1A1HSD17B10 | |
| (S)-Gatifloxacin SCHEMBL30910969 | 0.88 | KDM4E (1.00) | KDM4EKCNH2HPGDALDH1A1HSD17B10 | |
| (R)-Gatifloxacin SCHEMBL5670068 | 0.88 | KDM4E (1.00) | KDM4EKCNH2HPGDALDH1A1HSD17B10 | |
| Gatifloxacin SCHEMBL29356306 | 0.88 | KDM4E (1.00) | KDM4EKCNH2HPGDALDH1A1HSD17B10 | |
| (S)-Gatifloxacin SCHEMBL22592 | 0.88 | KDM4E (1.00) | KDM4EKCNH2HPGDALDH1A1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006004561-A1 | PROCESS FOR THE PREPARATION OF GATIFLOXACIN AND REGENERATION OF DEGRADATION PRODUCTS | KRKA, TOVARNA ZDRAVIL, D.D., NOVO MESTO (SI) | 2006-01-12 | — | — | WO | disclosed |